Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review

Niu, Jing; Li, Yanli; Wang, Junjun; Wang, Hui; Zhao, Ying; Zhang, Min

doi:10.1097/md.0000000000033651

Cited by 3 publications

(1 citation statement)

References 69 publications

(87 reference statements)

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“…Regarding the regeneration of cartilage tissue, this is a complex process in which the regenerated tissue does not usually present the original features, mainly due to low vascularization and innervation. In addition, the dense ECM limits chondrocyte migration and nutrient diffusion towards the injured area [136]. Conventional treatments (osteochondral autografts or allografts) show limited therapeutic efficacy in many cases and may also lead to post-traumatic osteoarthritis [137].…”

Section: Bone and Cartilage Regenerationmentioning

confidence: 99%

Advances in Biomedical Applications of Solution Blow Spinning

Carriles,

Nguewa,

González-Gaitano

2023

IJMS

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In recent years, Solution Blow Spinning (SBS) has emerged as a new technology for the production of polymeric, nanocomposite, and ceramic materials in the form of nano and microfibers, with similar features to those achieved by other procedures. The advantages of SBS over other spinning methods are the fast generation of fibers and the simplicity of the experimental setup that opens up the possibility of their on-site production. While producing a large number of nanofibers in a short time is a crucial factor in large-scale manufacturing, in situ generation, for example, in the form of sprayable, multifunctional dressings, capable of releasing embedded active agents on wounded tissue, or their use in operating rooms to prevent hemostasis during surgical interventions, open a wide range of possibilities. The interest in this spinning technology is evident from the growing number of patents issued and articles published over the last few years. Our focus in this review is on the biomedicine-oriented applications of SBS for the production of nanofibers based on the collection of the most relevant scientific papers published to date. Drug delivery, 3D culturing, regenerative medicine, and fabrication of biosensors are some of the areas in which SBS has been explored, most frequently at the proof-of-concept level. The promising results obtained demonstrate the potential of this technology in the biomedical and pharmaceutical fields.

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Section: Bone and Cartilage Regenerationmentioning

confidence: 99%