Thrombotest a New Method for Controlling Anticoagulant Therapy

Discrepancies in International Normalized Ratio Results between Instruments: A Model to Split the Variation into Subcomponents

“…STA-SPA 50 (Diagnostica Stago) was used as a reagent. It is a combined rabbit brain thromboplastin with added bovine plasma (Owren-based method) (9 ). Two different batches of the reagent were used in the study, with International Sensitvity Index (ISI) values of 1.00 and 1.02, respectively.…”

Poor Agreement among Prothrombin Time International Normalized Ratio Methods: Comparison of Seven Commercial Reagents

“…This obstacle has been circumvented by the concept of the International Normalized Ratio (INR). Prerequisite to this harmonization has been adoption by the WHO of an international reference thromboplastin preparation (13,14 ): each new commercial thromboplastin is calibrated against the primary WHO reference preparation. The results are used to calculate the relative sensitivity of the unknown preparation compared with the WHO standard International Sensitivity Index (ISI) (15 ).…”

External Quality Assessment of Point-of-Care Methods: Model For Combined Assessment of Method Bias and Single-Participant Performance by the Use of Native Patient Samples and Noncommutable Control Materials

“…tion ® (Diagnostica Stago) and the SPAϩ reagent (Diagnostica Stago), which is a combined rabbit brain thromboplastin with adsorbed bovine plasma (Owren method) (17 ). The final sample dilution is 1:21.…”