Thrombotic occlusive vasculopathy in a skin biopsy from a livedoid lesion of a patient with
            <scp>COVID</scp>
            ‐19

Llamas‐Velasco, M.; Muñoz‐Hernández, Patricia; Lázaro‐González, J.; Reolid‐Pérez, A.; Abad‐Santamaría, B.; Fraga, Javier; Daudén-Tello, Esteban

doi:10.1111/bjd.19222

Cited by 49 publications

(51 citation statements)

References 8 publications

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“…This may play a role in pathogenicity, as the data present co-localization of products linked to complement activation with SARS-CoV-2 spike glycoproteins. Llamas-Velasco et al [87] observed endothelial damage not only in kidney, small bowel and lung, but also in the dermo-hypodermal junction. These biological self-aggressive host behaviors run in the same pattern of the monogenic type I interferonpathies, but in COVID-19 is an acquired viral disease, acute and has a faster clinical evolution.…”

Section: Possible Actions Of Sars-cov-2 On Human Skin and The Resultimentioning

confidence: 99%

Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms

et al. 2020

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Background SARS-Cov-2 is a single-stranded RNA virus, a Betacoronavirus, composed of 16 non-structural proteins, with specific roles in replication of coronaviruses. The pathogenesis of COVID-19 is not yet fully understood. The virus and host factors interplay among distinct outcomes of infected patients. Methods Using MeSH (Medical Subject Headings) in PubMed, authors searched for articles cotaining information on COVID-19 and the skin. Results The pathophysiology of the disease is multifactorial: association with innate immune response, hypercoagulability state, lung tissue damage, neurological and/or gastrointestinal tract involvement, monocytic/macrophage activation syndrome, culminating in exaggerated cytokine secretion, called "cytokine storm", which leads to worsening and death. These systemic conditions may be associated with cutaneous lesions, that have polymorphic aspects, where at histopathological level show involvement in different skin changes. These lesions may be associated with multisystemic manifestations that could occur due to angiotensin-converting enzyme 2 receptor and transmembrane serine protease action, allowing the pulmonary infection and possibly skin manifestation. Several reports in literature show cutaneous lesions similar to chilblain, urticarial eruptions, diffuse or disseminated erythema, livedo racemosa, blue toe syndrome, retiform purpura, vesicle trunk, purpuric exanthema or exanthema with clinical aspects of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) and others. Conclusions This review describes the complexity of Covid-19, pathophysiological and clinical aspects, dermatological finding and other dermatological conditions associated with SARS-CoV-2 infection or COVID-19.

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Section: Possible Actions Of Sars-cov-2 On Human Skin and The Resultimentioning

confidence: 99%

Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms

et al. 2020

View full text Add to dashboard Cite

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“…Prominent acro-cyanosis has been described in severely ill patients but not sequelae secondary to skin necrosis. 3,4 In a recently published photographic atlas of COVID-19 patients from Spain, sizeable cutaneous ulceration was not observed. 1 Here, we describe three patients who developed large sacral/buttocks ulcers during their severe COVID-19 disease courses.…”

Section: Discussionmentioning

confidence: 99%

Large sacral/buttocks ulcerations in the setting of coagulopathy: A case series establishing the skin as a target organ of significant damage and potential morbidity in patients with severe COVID‐19

Young

Narang

Kumar

et al. 2020

International Wound Journal

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“…Furthermore, Llamas-Velasco et al [36] reported livedoid purple lesions along with acrocyanosis in a positive SARS-CoV-2 patient: at the biopsy, an obstructive cutaneous vasculopathy and sweat gland necrosis characterized by the presence of dilated blood vessels filled with hyaline thrombi and a mild neutrophilic component in the papillary dermis were detected; nonetheless, the microbiological cultures and PCR for SARS-CoV-2 infection for the skin biopsy were negative.…”

Section: Skin Pathologymentioning

confidence: 99%

“…Nevertheless, analyzing the most recent radiological data about SARS-CoV-2 pneumonia, it is clear that imaging features may be variable and patient-specific. Specifically, about 75% of subjects with bilateral lung [ 11 , 12 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] and multilobe involvement were also common [ 56 ]. In a case series of 21 patients affected by SARS-CoV-2, ground-glass opacity was the main imaging feature detected by chest CT [ 57 ], and 29% of these displayed consolidation [ 56 ].…”

Section: Radiological Aspects Of Sars-cov-2-related Diseasesmentioning

confidence: 99%

Imaging Diagnostics and Pathology in SARS-CoV-2-Related Diseases

Scimeca

Urbano

Bonfiglio

et al. 2020

IJMS

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In December 2019, physicians reported numerous patients showing pneumonia of unknown origin in the Chinese region of Wuhan. Following the spreading of the infection over the world, The World Health Organization (WHO) on 11 March 2020 declared the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak a global pandemic. The scientific community is exerting an extraordinary effort to elucidate all aspects related to SARS-CoV-2, such as the structure, ultrastructure, invasion mechanisms, replication mechanisms, or drugs for treatment, mainly through in vitro studies. Thus, the clinical in vivo data can provide a test bench for new discoveries in the field of SARS-CoV-2, finding new solutions to fight the current pandemic. During this dramatic situation, the normal scientific protocols for the development of new diagnostic procedures or drugs are frequently not completely applied in order to speed up these processes. In this context, interdisciplinarity is fundamental. Specifically, a great contribution can be provided by the association and interpretation of data derived from medical disciplines based on the study of images, such as radiology, nuclear medicine, and pathology. Therefore, here, we highlighted the most recent histopathological and imaging data concerning the SARS-CoV-2 infection in lung and other human organs such as the kidney, heart, and vascular system. In addition, we evaluated the possible matches among data of radiology, nuclear medicine, and pathology departments in order to support the intense scientific work to address the SARS-CoV-2 pandemic. In this regard, the development of artificial intelligence algorithms that are capable of correlating these clinical data with the new scientific discoveries concerning SARS-CoV-2 might be the keystone to get out of the pandemic.

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Thrombotic occlusive vasculopathy in a skin biopsy from a livedoid lesion of a patient with COVID ‐19

Cited by 49 publications

References 8 publications

Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms

Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms

Large sacral/buttocks ulcerations in the setting of coagulopathy: A case series establishing the skin as a target organ of significant damage and potential morbidity in patients with severe COVID‐19

Imaging Diagnostics and Pathology in SARS-CoV-2-Related Diseases

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