Thrombotic thrombocytopenic purpura

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a disease with a high rate of mortality if a proper treatment is not instated. Plasmapheresis with plasmatic exchange is the treatment of choice. Diagnosis is performed demonstrating microangiopathic hemolytic anemia, a negative direct Coombs test and thrombocytopenia. Among the clinical data, neurological and renal alterations stand out. When there is a reasonable suspicion in the diagnosis, plasmapheresis must be initiated immediately. There are different diseases that may be similar to the TTP signs and symptoms, especially in pregnant women. TTP has a high risk of relapse and may leave sequelae.

Anesthetic Management in a Parturient with Thrombotic Thrombocytopenic Purpura for Cesarean Section: A Case Report and Literature Review

“…These thrombi consist of PLT and ultra large vWF multimers. The net cause is a deficiency of ADAMTS13, leading to inability of disruption of vWF multimers [1]. In adults it is most often associated with acquired deficiency of ADAMTS13 due to auto-antibodies, whereas TTP in children is most often associated with a hereditary autosomal recessive severe deficiency of ADAMTS13 [2].…”

“…TTP can also be related to drugs, chemotherapy, and hematopoietic stem cell transplant. Clopidogrel, ticlopidine, cyclosporinA, mitomycin C, have been associated with triggering TTP [1].…”