“…Splenectomy, until recently a standard thera peutic modality, is presently controversial since there is little apparent rationale for its use in TTP [18,69,105]. Nonetheless, splenectomy has been as sociated with induction of TTP remission [9,25,40,66,73]. High doses of corticosteroids (up to 500 mg of prednisone or equivalent per day) are included in many treatment regimens.…”