Thrombotic Thrombocytopenic Purpura as A Cause of Massive Gastrointestinal Hemorrhage

Hellstrom, H. Richard; Nash, Emile C.; Fisher, Edwin R.

doi:10.1016/s0016-5085(59)80105-0

Cited by 12 publications

(2 citation statements)

References 6 publications

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“…3 Moreover, we suggest that abdominal pain, not considered classic of TTP, represents intra-abdominal ischemia, as it has been rarely described. 4-6 In the past year, we have seen two patients with ADAMTS13 deficiency that died with massive gastrointestinal ischemia and hemorrhage, confirmed by autopsy.…”

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confidence: 87%

First symptoms in patients with thrombotic thrombocytopenic purpura: what are they and when do they occur?

et al. 2013

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mentioning

confidence: 87%

First symptoms in patients with thrombotic thrombocytopenic purpura: what are they and when do they occur?

et al. 2013

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“…may be beneficial (Burke and Hartmann, 1959). The main clinical manifestations are fever, haemolytic anaemia, thrombocytopenia, purpura, and involvement of various organs with the relative exclusion of the lungs; the central nervous system and the kidneys are most often involved, but the myocardium (Frick and Hitzig, 1959), gastrointestinal tract (Hellstrom, Nash, andFisher, 1959), spleen (Gore, 1950), lymph nodes (Beigelman, 1951), and other organs are occasionally also clinically involved. The involvement of the central nervous system, which can appear at an early or late phase, is an almost constant feature.…”

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confidence: 99%

Thrombotic Thrombocytopenic Purpura

Bornstein¹,

Boss²,

Casper³

et al. 1960

J Clin Pathol

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A case of thrombotic thrombocytopenic purpura in a 50-year-old woman is described. Almost the whole course of the disease, lasting 18 months, was characterized by a bizarre neurological disorder, and the haematological manifestations first appeared at a late stage.In many organs a vast number of arterioles and capillaries contained plugs of a fibrinoid material, and fibrinoid was subendothelially accumulated in a few of these vessels; but, in addition, mediumsized arteries of the myocardium were also obstructed by this same material. There were also verrucal endocardiosis of the mitral valve and slight thickening of the glomerular basement membranes. The striking diffusion of a pathological substance through damaged cerebral vessel walls into the nervous tissue seems to be a significant contribution to the understanding of the pathogenesis of the vascular pathology of thrombotic thrombocytopenic purpura.

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Thrombotic Thrombocytopenic Purpura and Systemic Lupus Erythematosus

Levine¹,

Shearn²

1964

Arch Intern Med

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Thrombotic Thrombocytopenic Purpura as A Cause of Massive Gastrointestinal Hemorrhage

Cited by 12 publications

References 6 publications

First symptoms in patients with thrombotic thrombocytopenic purpura: what are they and when do they occur?

First symptoms in patients with thrombotic thrombocytopenic purpura: what are they and when do they occur?

Thrombotic Thrombocytopenic Purpura

Thrombotic Thrombocytopenic Purpura and Systemic Lupus Erythematosus

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