Thrombotic Thrombocytopenic Purpura in a Patient With Snake Bite

Murthy, Pooja R; Ak, Ajith Kumar; Karanth, Sunil; Kalashetty, Mallikarjun

doi:10.32677/ijcr.2019.v05.i03.028

Cited by 4 publications

(3 citation statements)

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“…In some presentations with VICC, a clinical picture compatible with TMA gives rise to end-organ failure, low platelet levels and MAHA. In venom-induced TMA, toxins act on von-Willebrand factor activation [1]. The coexistence of the overlapping features of VICC and TMA in envenomation is the possible explanation for snakebites resulting in DIC.…”

Section: Discussionmentioning

confidence: 99%

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An unusual case of hump-nosed-viper bite complicated with venom-induced thrombotic thrombocytopaenic purpura

Semina

Silva

2023

Preprint

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Background: Hump-nosed-viper bites are common in Sri Lanka resulting in nephrotoxicity and coagulopathy. Venom induced consumptive coagulopathy (VICC) is a known complication which occurs in absence of nephrotoxicity. Case Presentation: We report a case of hump-nosed-viper bite complicating with venom-induced thrombotic thrombocytopenic purpura (VITTP) of a 49 years old previously healthy male. Following envenomation, he developed anuria with acute kidney injury. The blood picture showed microangiopathic haemolytic anaemia with thrombocytopenia while the clotting profile was normal. A plausible diagnosis of VITTP was made per a high PLASMIC score (6/7). The patient underwent therapeutic plasma exchange (TPE) followed by high dose steroids along with renal replacement therapy. He made a full recovery. Conclusion: VITTP is a manifestation that needs to be differentiated from VICC in hump-nosed-viper bites.

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Section: Discussionmentioning

confidence: 99%

“…Murthy et al report a presentation of MAHA, AKI, thrombocytopenia, neurological impairment and fever following an unknown snake bite [1]. This patient was managed as TTP despite normal ADAMTS-13 levels making a full recovery.…”

Section: -7 Highmentioning

confidence: 99%

An unusual case of hump-nosed-viper bite complicated with venom-induced thrombotic thrombocytopaenic purpura

Semina

Silva

2023

Preprint

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“…It is characterized by increased microvascular platelet clumping resulting in thrombocytopenia and microangiopathic hemolytic anemia [1]. TTP is often accompanied by multiple organ dysfunction, renal failure, neurological abnormalities, and fever [7]. A large variety of unusual reactions and clinical manifestations have been reported following hymenoptera stings, including serum sickness neurological disorders, delayed hypersensitivity reaction 1, and renal disease [8].…”

Section: Discussionmentioning

confidence: 99%

Thrombotic Thrombocytopenic Purpura Following Honeybee Envenomation: A Case Report

Khalighi

Azami

Shafiei

et al. 2020

Int J Med Toxicol Forensic Med

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Background: Thrombotic Thrombocytopenic Purpura (TTP) is a rare and life-threatening disorder characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, fever, renal dysfunction, and neurological deficient. TTP leads to the formation of blood clots in small blood vessels throughout the body. TTP is associated with many risk factors such as pregnancy, HIV, cancer, lupus, and infections. Recently there have been few published case reports of bee sting associated TTP.Methods: A 67-year-old man from a rural area of the Southwest Province of Iran, Ilam, was referred to the academic general hospital because of fever, chills, sweating, vomiting and dizziness following the honeybee sting on his body. Results: this study showed that,multiple co-morbidities including CVD and diabetes, along with coagulation abnormalities after honeybee stings, seriously exacerbated patient hemodynamic status.Conclusion: TTP, as a major complication due to the toxic reaction of a large number of bee stings with underlying diseases in patients, should be given more attention.

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Venom-Induced Thrombotic Thrombocytopenic Purpura Following Hump-Nosed Pit Viper (Hypnale sp.) Bite: a Case Report

Semina,

Silva

2023

SN Compr. Clin. Med.

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Thrombotic Thrombocytopenic Purpura in a Patient With Snake Bite

Cited by 4 publications

References 0 publications

An unusual case of hump-nosed-viper bite complicated with venom-induced thrombotic thrombocytopaenic purpura

An unusual case of hump-nosed-viper bite complicated with venom-induced thrombotic thrombocytopaenic purpura

Thrombotic Thrombocytopenic Purpura Following Honeybee Envenomation: A Case Report

Venom-Induced Thrombotic Thrombocytopenic Purpura Following Hump-Nosed Pit Viper (Hypnale sp.) Bite: a Case Report

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