Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication

Gogireddy, Rajasekhar Reddy; Kumar, Vasanth; Ranjit, Suchitra; Natraj, Rajeswari; Venkatachalapathy, Priyavarthini; Jayakumar, Indira; Saravanan, Muthupandian

doi:10.1080/20469047.2019.1706299

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Previously, infection-induced TTP has been reported with shiga toxin-producing Escherichia coli, hepatitis A virus, dengue virus, influenza virus, and SARS-CoV-2 (Thrombotic Thrombocytopenic Purpura Associated With Escherichia Coli O157: H7-Washington, 1986;Bitzan and Zieg, 2018;Albiol et al, 2020;Gogireddy et al, 2020;Beaulieu et al, 2021;Montgomery et al, 2021). Previous research has revealed that congenital TTP (cTTP) can be triggered by S. enterica infection (Wendt et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Flavorubredoxin, a Candidate Trigger Related to Thrombotic Thrombocytopenic Purpura: Screening of the Complete Genome of a Salmonella enterica Serovar Typhimurium Isolate From an AIDS Case

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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Thrombotic thrombocytopenic purpura (TTP) is one of the two classic thrombotic microangiopathy (TMA) diseases which could be induced by infections. To the best of our knowledge, this is the first report of an acquired immunodeficiency syndrome (AIDS) patient with acquired TTP induced by infection with Salmonella enterica serovar Typhimurium (hereafter, S. Typhimurium) isolate, S. Typhimurium_zhang, which was confirmed by serology and genetic taxonomy. The literature review identified 17 TMA-related genes encoding the candidate triggers, which were searched in the annotated genome sequence of S. Typhimurium_zhang. Anaerobic nitric oxide reductase flavorubredoxin (FlRd), encoded by norV which is related to another TMA, haemolytic uraemic syndrome (HUS), was found in S. Typhimurium_zhang. Basic local alignment search tool (BLAST) analysis revealed that norV and FlRd in S. Typhimurium_zhang, as well as eight S. Typhimurium type strains, have high identity with HUS-related Escherichia coli O157:H7 strain TW14359. Similar results were obtained from the BLAST analysis of 73 S. enterica isolates for congenital TTP which was also previously reported to be triggered by S. enterica. Phylogenetic analysis and amino acid sequence alignment revealed that FlRd was functional and highly conservative on 69 Enterobacteriaceae, including S. Typimurium_zhang and TW14359. In brief, we found norV in the genome of a S. Typhimurium clinical isolate that induced TTP in an AIDS patient. FlRd, the protein encoded by norV, probably triggered the TTP and was highly conservative, functional, and widespread in S. enterica and Enterobacteriaceae. More in vitro and in vivo studies are required to confirm our findings and determine the underlying mechanism.

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Section: Introductionmentioning

confidence: 99%

Flavorubredoxin, a Candidate Trigger Related to Thrombotic Thrombocytopenic Purpura: Screening of the Complete Genome of a Salmonella enterica Serovar Typhimurium Isolate From an AIDS Case

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…reviewed and are listed below: • Shigatoxin (STEC-HUS) producing enterobacteria: E. coli is the most common, the others include Shigella dysenteriae, Campylobacter jejuni, Moraxella osloensis • Viral infections: cytomegalovirus, Epstein-Barr virus, varicella zoster virus, parvovirus B19, human immunodeficiency virus, influenza virus • Respiratory tract infection agents: Bordetella pertussis, Streptococcus pneumoniae(16), Mycoplasma pneumoniae(93).• Protozoa: Toxoplasma gondii.• Rare agents: erlichiosis(94), Capnacytophaga canimorsus(95,96), Plasmodium vivax (malaria)(97), snakebites (Bothrops jararaca)(98), dengue fever(99)(100)(101), West Nile virus(102); Chikungunya Fever(103,104).• Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) Mechanisms of TMA-associated with infectious diseases are complex and include direct endothelial injury, development of ADAMTS13 inhibitors and complement activation inJ o u r n a l P r e -p r o o f different levels and magnitude. As an illustration, putative mechanisms of TMA in influenza infection are production of neuraminidase (although lower than seen with Streptococcus pneumoniae), direct infection of endothelial cells leading to apoptosis, activation of platelets and generation of thrombin.…”

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confidence: 99%

Complement in Secondary Thrombotic Microangiopathy

Palma

Sridharan

Sethi

2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Dengue Mimickers: Which Clinical Conditions Can Resemble Dengue Fever?

Farias,

Costa,

Bessa

et al. 2024

Rev. Soc. Bras. Med. Trop.

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Epidemics and outbreaks caused by the dengue virus pose risks to populations and have high mortality rates, causing burdens and economic costs worldwide. Brazil recently experienced an explosive increase in the number of dengue cases and fatalities. Dengue is an acute febrile illness that can progress to severe forms. It affects more than 100 countries, presenting ongoing challenges in Brazil and globally since its identification. Other conditions may be overlooked or mistaken for dengue. The most important differential diagnoses are other infectious diseases and rheumatological, hematological, gastroenterological, and neurological disorders. In this article, we discuss the primary differential diagnoses of dengue and offer a literature review highlighting the key clinical differences among clinicians. This review emphasizes the critical importance of differentiating dengue fever from infectious diseases such as meningococcemia and malaria and autoimmune and rheumatological conditions such as systemic lupus erythematosus to ensure timely and appropriate management.

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Thrombotic thrombocytopenic purpura in a 2.5-year-old boy with dengue infection: a rare complication

Cited by 3 publications

References 13 publications

Flavorubredoxin, a Candidate Trigger Related to Thrombotic Thrombocytopenic Purpura: Screening of the Complete Genome of a Salmonella enterica Serovar Typhimurium Isolate From an AIDS Case

Flavorubredoxin, a Candidate Trigger Related to Thrombotic Thrombocytopenic Purpura: Screening of the Complete Genome of a Salmonella enterica Serovar Typhimurium Isolate From an AIDS Case

Complement in Secondary Thrombotic Microangiopathy

Dengue Mimickers: Which Clinical Conditions Can Resemble Dengue Fever?

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