2017
DOI: 10.1007/s12026-017-8898-y
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Thrombotic thrombocytopenic purpura in a new onset lupus patient?

Abstract: We are presenting a case of TTP with undetectable levels of ADAMTS 13 in a 39-year-old woman. Diagnosis of systemic lupus was evoked in the setting of thrombotic microangiopathy. The patient presented normal renal function but important neurological impairment. Treatment with daily plasmapheresis as well as Rituximab, cyclophosphamide as steroids was required to achieve clinical improvement.

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Cited by 5 publications
(4 citation statements)
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“…This treatment should be continued until the first platelet counts appear within normal limits for two consecutive days. 11 However, in this report the plasma exchange treatment was momentarily discontinued after four days even though the platelet level was not in the normal range. This approach was applied because, according to the consensus of experts in our hospital, the patient showed a favorable laboratory pattern in which the platelet level increased and the LDH concentration decreased.…”
Section: Discussionmentioning
confidence: 69%
“…This treatment should be continued until the first platelet counts appear within normal limits for two consecutive days. 11 However, in this report the plasma exchange treatment was momentarily discontinued after four days even though the platelet level was not in the normal range. This approach was applied because, according to the consensus of experts in our hospital, the patient showed a favorable laboratory pattern in which the platelet level increased and the LDH concentration decreased.…”
Section: Discussionmentioning
confidence: 69%
“…Plasma exchange independent of ADAMTS13 activity is important and is recommended until the first platelet counts appear within normal limits for two consecutive days. 10 TTP should always be considered in patients with hemolytic anemia and thrombocytopenia; however, in young women, SLE and TTP can occur simultaneously.…”
Section: Discussionmentioning
confidence: 99%
“…However, although there are case reports and single-arm reports reporting the effect of RTX on CTDassociated TTP/TMA [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], with some reports of exacerbations [31], there are no studies comparing an RTX-intervention group to a control group. In our department, RTX has been administered for CTDassociated refractory TTP/TMA after obtaining ethics committee approval and written consent.…”
Section: Introductionmentioning
confidence: 99%