Thrombotic Thrombocytopenic Purpura: Report of a Case with Discussion of Its Tinctorial Features

Fisher, Edwin R.; Creed, Donald L.

doi:10.1093/ajcp/25.6.620

Cited by 22 publications

(1 citation statement)

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“…Although fibrin as well as hemoglobin may be iden tified within the wall and "hyaline thrombi" of the lesion ofTTP; it has been noted that much of the material is argyrophilic, resists tryptic digestion and is colored orange by the phosphotungstic acid hematoxylin technic. These tinctorial features resemble those of fibrinoid as encountered in rheumatoid nodules but are unlike those of the fibrin in blood clots (122). Identical histochemical features of the vascular lesions and damaged smooth muscle have also been observed (19).…”

Section: Thrombotic Thrombocytopenic Purpura (Ttp)mentioning

confidence: 92%

A Consideration of the so-called Collagen or Systemic Connective Tissue Diseases (Part 2 of 2)

Criep¹

1959

Int Arch Allergy Immunol

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Section: Thrombotic Thrombocytopenic Purpura (Ttp)mentioning

confidence: 92%

A Consideration of the so-called Collagen or Systemic Connective Tissue Diseases (Part 2 of 2)

Criep¹

1959

Int Arch Allergy Immunol

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Thrombotic Thrombocytopenic Purpura

Burke¹

1959

AMA Arch Intern Med

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In 1954, Singer reviewed the subject of thrombotic thrombocytopenic purpura, collecting 55 cases from the literature.1 Wile and Sturgeon, in 1956, compiled an additional 19 instances and added 3 case reports in children.2 We are aware of an additional 25 reports during the years 1954-1957, bringing the total number of cases to over 100 In general the clinical course of this disorder has been most unfavorable, the majority of patients dying within eight weeks of the recognized onset of the disease.In rare instances survival for more than one year has been reported.23,24,26,28,29 Several of these patients had atypical manifestations, so that it is difficult to ascertain the time of onset of the disease and the survival time in all of these cases.No well-documented typical case has undergone long-term spontaneous remission, and a variety of therapeutic endeavors has in general failed to influence the course of the disease. There have been no prolonged remissions reported following the use of corticotropin (ACTH) or steroids alone, but in four instances temporary improvement did take place, lasting for 36 days in one patient10 and for 13 days in another.28 The other two patients received steroids, im¬ proved, and were then splenectomized.26,29Only one remission longer than one year has followed splenectomy alone.28Four patients have remitted following treatment with both steroids and splenec¬ tomy.23·24'26·29 On the other hand, splenec¬ tomy and steroids or corticotropin alone or in combination have apparently failed in most reported cases (e. g., references 1-7, 10, [15][16][17][18][19][20][21]25,[27][28][29][30][31][32][33][34][35]. In most instances the amount of steroid employed was not large, and frequently the use of these drugs was restricted to the last few days of life. The present report documents two cases with long-term and continuing remission follow¬ ing the use of large amounts of steroids. Report of CasesCase 1.-A 26-year-old white farmer was ad¬ mitted to the Vanderbilt University Hospital in a confused and disoriented state on June 17, 1955. Three years prior to admission he experienced tem¬ porary loss of consciousness but no other obvious sequelae following an automobile accident. From 1953 to the time of admission there were several attacks of syncope. Otherwise the patient had been in excellent health until the sudden onset of frontal headache, "tingling" paresthesias of the right arm, and weakness of the right side of the body three weeks prior to admission. Within 24 hours he became asymptomatic and returned to work.Ten days before admission there had occurred an episode of dysarthria, confusion, numbness of the face, weakness of the extremities, and vomiting of a small amount of blood. These manifestations lasted but 12 hours, and the patient continued to work despite subsequent repeated occurrence of acroparesthesias lasting 1-60 minutes. His associ¬ ates noted "yellow eyes." Two days before ad¬ mission there was another attack of confusion, "tremors all over," dysarthria, numbness and weak...

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Thrombotic Thrombocytopenic Purpura and Systemic Lupus Erythematosus

Levine¹,

Shearn²

1964

Arch Intern Med

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Thrombotic Thrombocytopenic Purpura: Report of a Case with Discussion of Its Tinctorial Features

Cited by 22 publications

References 0 publications

A Consideration of the so-called Collagen or Systemic Connective Tissue Diseases (Part 2 of 2)

A Consideration of the so-called Collagen or Systemic Connective Tissue Diseases (Part 2 of 2)

Thrombotic Thrombocytopenic Purpura

Thrombotic Thrombocytopenic Purpura and Systemic Lupus Erythematosus

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