Thromboxane as a Measure of Cutaneous Vascular Damage Following Irradiation

Ws, Dernell; Lg, Wheaton; Pr, Gavin; Cw, Leathers; Rw, Leid

doi:10.1097/00006534-199406000-00020

Cited by 2 publications

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“…in coronary (20) and cerebral vasoconstriction, (21) in decubitus ulcers (22) and in skin burns. (23) Thromboxane A 2 is decomposed to thromboxane B 2 , a stable compound, and Dernell (24) found a relationship between a high level of thromboxane B 2 and the histological degree of skin injury.…”

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confidence: 99%

Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension

et al. 1998

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Objective: To analyze variations in leukocyte count and thromboxane B 2 production in the femoral vein of patients with chronic venous hypertension (CVH). Design: Prospective clinical study, controlled, non randomized and open. Location: Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, referral center, university hospital. Participants: 15 patients with recurring stasis ulcer were analyzed, selected randomly from the venous diseases outpatient center, and 4 without lower limb venous alterations were also analyzed. Intervention: Blood samples from the femoral and brachial veins were drawn following supine and 45º reverse Trendelenburg. Main outcomes measures: Direct leukocyte count and analysis of the thomboxane B 2 with enzyme linked immunosorbent assay test. Results: After 30 minutes in reverse Trendelenburg, patients with CVH showed a leukocyte count reduced by ±27% (p=0.02) and thromboxane B 2 levels increased by ±158% (p=0.02). Conclusions: We suggest that future studies of medications for stasis ulcers include their effects on leukocyte entrapment and thromboxane B 2 production in the lower limb venous system.

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