Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction

Abstract

Routine thrombus aspiration before PCI as compared with PCI alone did not reduce 30-day mortality among patients with STEMI. (Funded by the Swedish Research Council and others; ClinicalTrials.gov number, NCT01093404.).

Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial

“…This conclusion is confirmed by the neutral results of the TASTE (n=7244) and TOTAL (n=10 732) trials, both of which were specifically designed to reliably detect differences in clinical outcomes. 7,8 The findings of TOTAL are also consistent with the Intracoronary Abciximab and Aspiration Thrombectomy in Patients with Large Anterior Myocardial Infarction (INFUSE AMI) trial, 26 which showed no difference in infarct size with routine thrombus aspiration.…”

“…7 However, TASTE was a registrybased trial that relied on discharge diagnosis codes without adjudication. Moreover, in the TAPAS trial, stroke was not a prespecified outcome and was not reported.…”

“…At long-term follow-up at 1 year, the TAPAS trial also showed a significant reduction in mortality that was not apparent at 30 days. 6 By contrast, the larger Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia (TASTE) trial 7,8 of 7244 patients showed no significant reduction in mortality either at 30 days or at 1 year.…”

A Case of Thrombus Aspiration Catheter Trapped in Coronary Artery Due To Rupture of its Main Shaft and Twisting Over the Wire

“…However, there is still much debate about the utility of routine usage of thrombus aspiration catheters in STEMI patients. Some recent studies demonstrated that routine usage of this device may not improve mortality or bring any advantages in that field [4,5].…”

CORR Insights®: The Role of Highly Selective Implant Retention in the Infected Hip Arthroplasty

“…As long as the registry is capable of identifying patients with a partial hip revision, the concept of the registryembedded study [5] is probably the most-realistic tool for getting answers regarding the efficacy of partial hip revision in PJI. In registry-embedded studies, both an observational design and a randomization design [10] are possible.…”