Three-dimensional (3D) integration is an emerging technology that is revolutionizing the semiconductor industry. On one hand, it enables the packaging of more devices per unit volume, also referred to as “More Moore”, while on the other hand, it empowers multifunctionality, also known as “More than Moore”, both of which are key toward the development of low-cost, energy-efficient, and high-performance smart electronic systems. While silicon-based 3D integrated circuits (ICs) are already commercially available, there is limited effort on 3D integration of emerging nanomaterials such as two-dimensional (2D) materials despite their novel functionalities that may benefit many applications. Here we demonstrate monolithic 3D integration of a large volume (in excess of 600 transistors in each tier) of aggressively scaled field effect transistors (FETs) based on monolayer MoS2 at low-thermal budget (with processing temperature < 185 °C). We also realize 3D circuits and demonstrate multifunctional capabilities including sensing, memory storage, as well as logic gates in any tier across the 3D stack. We believe that our demonstration will pave the path for more sophisticated, highly dense, and functionally divergent ICs with a larger number of tiers integrated monolithically in the third dimension.