Thryroid Hormones and Hematological Indices Levels in Thyroid Disorders Patients at Moi Teaching and Referral Hospital, Western Kenya

Abstract

Problem Statement. Thyroid disorders are prevalent in western Kenya, but the effects of disorders on thyroid hormones and hematological indices levels have not been documented. Study Population. Patients treated for thyroid disorders at the MTRH between January 2008 and December 2011. Objectives. To determine the thyroid hormones and hematological indices levels in thyroid disorders patients at the MTRH, western Kenya. Methodology. A retrospective study in which patient data and stored samples of patients, who presented with thyroid pathologies, underwent thyroidectomy, and histological examinations are done. Thyroid stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) blood levels, white blood cells (WBCs), red blood cells (RBCs), platelet counts, and hemoglobin (Hb) levels were analyzed. Results. Male : female ratio was 1 : 10.9 with female representing 368 (95%). The median age was 41 (IQR: 32–48) with a range of 14–89 years. HHormonal levels for immunological thyroid disease patients were higher (P = 0.0232; 0.040) for TSH and (T3) for those aged 30–39 years, respectively. The WBCs, RBCs, HGB, and platelets in immunological thyroid disease were not statistically significant with P values of 0.547, 0.205, 0.291, and 0.488 respectively. Conclusion. The presence of anaemia due to low RBCs in thyroid disease is not significantly associated with thyroid hormone with a P value of 0.512.

Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study

“…The most prevalent hematological disorder with thyroiditis is anemia and it is indicated by a decrease in the number of RBCs and hemoglobin concentration. [8,11,13,16,19] The present report correlates with the aforementioned findings as a significant decrease was observed in the number of RBCs, hemoglobin concentration, PCV, and MCH between the thyroid disorder and normal thyroid groups and the prevalence of anemia increased by threefold with thyroid dysfunction compared with euthyroid females. Although anemia was reported with different types of thyroiditis, it is more common in hypothyroidism compared to hyperthyroidism.…”

“…Although anemia was reported with different types of thyroiditis, it is more common in hypothyroidism compared to hyperthyroidism. [3,7,8,11,14,16] The decreased prevalence of anemia with hyperthyroidism could be explained by the observed increase in erythrocytosis. [8,16] The current study supports the earlier observations as it showed a significant increase in the prevalence of anemia in the overt and occult hypothyroidism groups compared to normal thyroid group.…”

“…[1,3,[10][11][12][13][14][15] Thyroid disorders are associated with hematological abnormalities and anemia is the most prevalent disorder. [6,12,[16][17][18] Early reports have shown a decrease in the number of red blood cells (RBCs) in the peripheral blood of patients after thyroidectomy [19] and anemia has been defined in 20-60% of the patients with hypothyroidism. [7,8,16] Although early reports showed that Graves' disease is also associated with hematological disorders, [11,14,15] anemia is not frequently observed in patients with hyperthyroidism, whereas erythrocytosis is common.…”

“…[6,12,[16][17][18] Early reports have shown a decrease in the number of red blood cells (RBCs) in the peripheral blood of patients after thyroidectomy [19] and anemia has been defined in 20-60% of the patients with hypothyroidism. [7,8,16] Although early reports showed that Graves' disease is also associated with hematological disorders, [11,14,15] anemia is not frequently observed in patients with hyperthyroidism, whereas erythrocytosis is common. [8,15,16] Furthermore, it has been found that all hematological parameters return to normal when a euthyroid state is achieved.…”

“…[7,8,16] Although early reports showed that Graves' disease is also associated with hematological disorders, [11,14,15] anemia is not frequently observed in patients with hyperthyroidism, whereas erythrocytosis is common. [8,15,16] Furthermore, it has been found that all hematological parameters return to normal when a euthyroid state is achieved. [14,[20][21][22][23] Females are more prone to the development of thyroid disorders and/or anemia, especially during the reproductive age and pregnancy.…”