THU-073-The use of APRI and FIB-4 scores versus transient elastography for the assessment of liver fibrosis stage in patients with chronic hepatitis C: Is it possible to reduce the need for elastography?

Papadopoulos, Nikolaos; Vasileiadi, Sofia; Michalea, Stavroula; Antonakaki, Pinelopi; Papavdi, Maria; Dellaporta, Erminia; Koullias, Emmanouel; Koutli, Evaggelia; Manolakopoulos, Spilios; Koskinas, Ioannis-Georgios; Deutsch, Melanie

doi:10.1016/s0618-8278(19)30354-8

Cited by 2 publications

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“…[ 16 ] Recently, researches are conducted to define a threshold cut-off for both biochemical scores to diagnose severe liver fibrosis to defer TE. [ 7 17 ] FIB outperforms APRI, with a score of less than 1.08-1.2 as a threshold to exclude severe liver fibrosis found in different population. [ 11 13 ] Because of all the challenges associated with the assessment of liver fibrosis, WHO and EASL recommend using APRI and FIB-4 to guide monitoring and treatment decisions in HCV patients for a cost-effective care plan.…”

Section: Introductionmentioning

confidence: 99%

Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan

Ishtiaq

Shah

Iftikhar

et al. 2020

J Family Med Prim Care

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Objective: We aimed to study the extent of liver fibrosis in chronic hepatitis C patients with indeterminate APRI score of ≥ 0.5 - ≤2 (between higher and lower cut off value) and correlate it to transient elastography (TE) and FIB 4 index. Method: A cross-sectional study, 80 patients with CHC mono infection, APRI score ≥ 0.5 - ≤2 were interviewed from the cohort visiting the CHC program clinic at a tertiary care hospital in Karachi, Pakistan. Data were analyzed using STATA 14.0 and R 3.5.2 and SPSS 24.0 software according to their capabilities. Result: Of 80 patients, 50 (62.5%) were females and 30 (37.5%) were males with mean (±SD) ages of 41.73 (±11.5) years and 41.16 (±9.24) years respectively. The FIB 4 value among indeterminate APRI was reported as 1.47 (IQR 1.05-2.43). TE categories was reported: F0-F1 ( n = 29; 36%), F1-F2 ( n = 10; 12.5%), F2 ( n = 9; 11.2%) F3 ( n = 13; 16.2%), F3-F4 ( n = 1; 1.2%) F4 ( n = 18; 22.5%). FIB4 had a moderate positive correlation with TE while a weak positive correlation was found between APRI and TE (0.488, P < 0.0001 and 0.289, P < 0.001, respectively). TE was taken as a gold standard and compared with FIB4. The model constructed reported FIB4 as a good prediction for liver fibrosis with diagnostic accuracy 72%. Conclusion: The combination of two serum markers proves to be a low-cost noninvasive testing strategy for CHC patients having an indeterminate APRI score. By being readily accessible both biochemical scores can simplify liver assessment in lower middle-income countries (LMIC) and help family physicians to take appropriate decisions about treatment initiation with minimum delays.

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Section: Introductionmentioning

confidence: 99%

Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan

Ishtiaq

Shah

Iftikhar

et al. 2020

J Family Med Prim Care

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Changes in Fibrosis Under the Influence of Treatment of Patients With Alcoholic Cirrhosis of the Liver in Combination With Obesity Using Ademethyaninium and Arginine Glutamate

Matkovska

2020

Clin. and prev. med.

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Aim: to study the changes in liver parenchymal fibrosis under the influence of treatment of patients with alcoholic liver cirrhosis in combination with obesity using ademethionine and arginine glutamate. Material and methods. 215 patients, diagnosed with alcoholic liver cirrhosis (ALC), took part in the study, including 66 women and 149 men aged (48.1±9.7) years and a median disease duration (5.8 ± 2.6) years. 109 people had ALC with obesity (group I) and 106 people had ALC without obesity (group II). Patients were divided into subgroups depending on the stage of decompensation according to Child-Pugh: class A – group IA (n=40), class B – group IB (n=39), class C – group IC (n=30) and IIA (n=39), IIB (n=36), IIC (n=31) groups, respectively. Depending on the treatment protocol (b protocol – basic therapy, h protocol – basic therapy in combination with ademethionine and arginine glutamate), all patients were divided into subgroups. Results. In patients with ALC in combination with obesity, the elasticity of the liver parenchyma according to shear wave elastography and the FIB-4 index were higher than classes A, B and C compared to those in patients with ALC without obesity. According to the study results, obese patients with ALC had a more severe course of ALC according to the Child-Pugh and MELD scores. There is a direct relationship between the level of fibrosis in patients with ALC in combination with obesity according to elastography and the FIB-4 index with the severity of the disease according to the Child-Pugh ad MELD scores. The inclusion of ademethionine and arginine glutamate in the treatment regimen has improved the general condition of patients, compensated for clinical and laboratory parameters and reduced the rate of progression of liver fibrosis. Conclusion. In patients with ALC in combination with obesity, the inclusion in the treatment of ademethionine and arginine glutamate has improved the course of the disease, as evidenced by changes in the parameters of the disease severity by Child-Pugh and MELD scores, and helped to reduce the rate of progression of liver fibrosis according to elastography and the FIB-4 index.

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THU-073-The use of APRI and FIB-4 scores versus transient elastography for the assessment of liver fibrosis stage in patients with chronic hepatitis C: Is it possible to reduce the need for elastography?

Cited by 2 publications

References 0 publications

Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan

Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan

Changes in Fibrosis Under the Influence of Treatment of Patients With Alcoholic Cirrhosis of the Liver in Combination With Obesity Using Ademethyaninium and Arginine Glutamate

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