THU0082 Anti-P. Gingivalis Antibody is Correlated with Severity of Periodontitis (PD) but not with Rheumatoid Arthritis (RA) Disease Activity in RA

Abstract

Background Periodontitis (PD) has been suggested to be one of risk factors for rheumatoid arthritis (RA). Porphyromonas gingivalis (P. ginvivalis, Pg) is a gram-negative anaerobic bacterium that is recognized as a major pathogenic organism in periodontitis (PD). Anti-enolase 1 (ENO1) antibody is one of the autoantibodies in RA. Objectives This study examined the relationship between serum levels of anti-Pg and anti-ENO1 antibodies and PD severity and RA disease activity in patients with RA. Methods 246 Patients with RA and 85 age-, sex- matched non-RA controls were enrolled in this study. After rheumatologic and periodontal examination, serum levels of anti-Pg antibodies and anti-ENO1 antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Results Patients with RA showed significantly higher levels of anti-Pg antibodies and, anti-ENO1 antibodies than controls (P= 0.002, P= 0.02). Anti-Pg antibodies were strongly correlated with anti-ENO1 antibodies in RA patients (p<0.0001). In active RA, there were significant correlations between anti-Pg antibodies with probing pocket depth (PPD) and clinical attachment level (CAL) (P= 0.0014, P=0.0059). However, there were no correlations of anti-Pg antibodies and periodontal parameters in controls and inactive RA. Anti-ENO1 titer did not correlate with periodontal parameters except bleeding on probing (BOP) in RA. Anti-Pg antibodies were not correlated with RA disease activity except ESR (p= 0.0357). However anti-ENO1 antibodies were significantly correlated with ESR, DAS28-ESR, anti-CCP titer (P= 0.0008, P= 0.0092, P= 0.0129). Conclusions Anti-Pg antibodies and anti-ENO1 antibodies were elevated in RA patients than controls. Anti- Pg antibodies were correlated with severity of PD and anti-ENO1 antibodies were correlated with RA disease activity in RA patients. Disclosure of Interest None Declared