THU0171 Increased functional activity of foxp3+regulatory t cells in the peripheral blood of dmards-naÏve methotrexate-treated patients with early ra using
Abstract:ObjectivesTo analyze the effect of methotrexate (MT) therapy on the percentage and absolute number of FoxP3+ regulatory T (Treg) cells in the peripheral blood of MT-naïve patients (pts) with early RA we used Treg immunostainingwith antibodies to surface markers and Foxp3 with subsequent flow cytometric analysisMethods45 MT-naïve pts with early RA (39 females, Me;IQR age 52.0 (32.5–57.5) years, RA duration 5 (4–6) months, DAS 28 5.01 (4.18–5.8), RF positive -71.1%, ACPA - positive-88.9%) were included into the … Show more
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