Poster Presentations 2019
DOI: 10.1136/annrheumdis-2019-eular.1881
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Thu0336 developing a Novel Rapid Ex Vivo Model of Skin Fibrosis for Systemic Sclerosis Research

Abstract: BackgroundSystemic Sclerosis (SSc) is an autoimmune disease that causes tissue fibrosis in multiple systems. Immune dysfunction and dysregulation are known to play a role in the disease, but the pathophysiology of SSc is not clearly understood.(1) Adipose-derived stromal cells (ADSCs) reside in the dermal white adipose tissue (DWAT) and have reparative and regenerative functions.(2) We have previously shown that ADSCs are lost in SSc and that injecting these along with a survival signal can partially reverse f… Show more

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