THU0433 The prevalence of spondyloarthropathy in patients with takayasu arteritis

Abstract

BackgroundTakayasu arteritis (TA) is characterised by inflammation of large arteries causing stenosis, occlusion, dilatation and/or aneurysm of affected vessels. TA is most commonly seen in younger women between 20–30 ages. Etiopathogenesis of TA is largely unknown although evidence suggest complex interplay between environmental and genetic factors such as HLA (human leukocyte antigen) groups. The coexistence of TA with spondyloarthropathies (SPA) has been reported in limited case series, raising hypotheses about shared pathogenetic mechanisms.ObjectivesTo determine prevalence of spondyloarthropathy in patients with TA.MethodsDetailed clinical and demographic features of TA patients were recorded and all were screened for the presence of SPA following recommendations of (ASAS). Patients were questioned for inflammatory back pain, enthesitis, uveitis, inflammatory bowel disease, peripheral arthritis, and investigated accordingly with HLA-B27, plain X-rays of pelvis and sacroiliac magnetic resonance imaging. Radiographic spondyloarthritis was reported in case of bilateral grade ≥2 or unilateral grade ≥3 sacroiliitis.ResultsThere were 65 patients (61 female, 4 male) in the cohort. Mean age was 43±13 years and age at the diagnosis of TA was 35±13 years. Inflammatory bowel disease, psoriasis and psoriatic arthritis were observed in four, three and one patients. Chronic axial pain was reported by 26 (40%) patients but inflammatory back pain was evident in 13 (20%) patients. Chronic arthritis was observed in 4 patients. HLA-B27 was positive in three patients. Six patients were diagnosed as radiographic SPA and 3 were diagnosed as non-radiographic SPA. In sum nine patients were diagnosed as SPA (14.2%).ConclusionsOur study demonstrated that SPA is common in patients with Takayasu arteritis suggesting shared pathogenetic mechanisms.Disclosure of InterestNone declared