Thymectomie et infection virale chez l’homme

The thymus is the central site for the differentiation and selection of T cells. It has been known for decades that B lymphocytes reside in the thymus, but little attention has been paid to this unique population. Thymic B cells are mainly located in the medulla and at the cortico-medullary junction. They develop intrathymically, do not recirculate and harbor a distinct phenotype in comparison to peripheral B cells. Furthermore, because of their activated phenotype and their precise histological localization, they have been suspected to play a role in the selection of self-reactive T cells. But it is only during this last decade that murine and human studies have highlighted their functions, such as antigen-presenting cells shaping the T cell repertoire. These works have demonstrated the major role of thymic B cells in the immune system.

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Les lymphocytes B thymiques : plus que de simples spectateurs de la lymphopoïèse T

Gies

Guffroy

Korganow

2017

Med Sci (Paris)

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Thymectomie et infection virale chez l’homme

Cited by 1 publication

References 10 publications

Les lymphocytes B thymiques : plus que de simples spectateurs de la lymphopoïèse T

Les lymphocytes B thymiques : plus que de simples spectateurs de la lymphopoïèse T

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Thymectomie et infection virale chez l’homme

Cited by 1 publication

References 10 publications

Les lymphocytes B thymiques : plus que de simples spectateurs de la lymphopoïèse T

Les lymphocytes B thymiques : plus que de simples spectateurs de la lymphopoïèse T

Contact Info

Product

Resources

About

Les lymphocytes B thymiques : plus que de simples spectateurs de la lymphopoïèse T

Les lymphocytes B thymiques : plus que de simples spectateurs de la lymphopoïèse T