Thymic Carcinoma Treated by CyberKnife Stereotactic Body Radiotherapy

Harada, Yasuhiro; Miyazaki, Shôzo

doi:10.7759/cureus.1056

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…SBRT with CyberKnife requires a highly conformal technique to deliver high-dose radiation in 5 or fewer treatment fractions, it is characteristic of less fraction and lower radiation effect to the surrounding organs. Harada Y. et al 17 . reported ten patients of thymoma treated by CyberKnife.…”

Section: Discussionmentioning

confidence: 98%

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Prospective Study of Stereotactic Body Radiation Therapy for Thymoma and Thymic Carcinoma: Therapeutic Effect and Toxicity Assessment

Hao

Peng

Zhou

et al. 2017

Sci Rep

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Stereotactic body radiation therapy (SBRT) is an important modality in treatment of tumors. We hypothesized that SBRT can achieve excellent local control with limited toxicity in patients with thymic tumors. A single-institution prospective study was performed with 32 patients who underwent SBRT of thymoma and thymic carcinoma between 2005 and 2014. Thirty-two patients including 39 target lesions were analyses in this study. Almost half of the patients (46.9%) were type C by histopathology and more than half (56.3%) were classified into stage IVA or IVB. The median dose of SBRT for gross tumor volume (GTV) was 56 Gy (range 49–70 Gy). Results showed that the response rate was 96.9% after SBRT and the median tumor shrinkage rate was 62.2% (range 3.8–100%). For the patients with both stage II–III and type A-B (n = 6), the median PFS was 28 months. In-field failure was only observed in 4 patients, and outside-field failure was seen in 2 patients. The local control rate was 81.25%. Patients treated with SBRT had an excellent local control with mild toxicities, which suggests that SBRT is feasible for the patients with thymic tumors who are unable to undergo either surgery or conventionally fractionated radiation therapy.

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Section: Discussionmentioning

confidence: 98%

“…There are five studies with 19 cases of SBRT for thymoma reported at present and the results showed that SBRT for thymoma was effective as well with low toxicities 13 – 17 . However, the number of the cases is too small and, no prospective studies reported until now.…”

Section: Introductionmentioning

confidence: 93%