Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+T cell pathogenicity in non-obese diabetic mice
Chia-Lo Ho,
Li-Tzu Yeh,
Yu-Wen Liu
et al.
Abstract:Our understanding of autoimmune diabetes underscores the critical involvement of CD8+T cells recognizing islet-specific antigens. However, the influence of thymic positive selection on diabetogenic CD8+T cell development remains unclear. Using CD5 marker representing T-cell receptor (TCR) signal strength, we illustrated that naïve CD5hiCD8+T cells of non-obese diabetic (NOD) mice with enhanced TCR signals displayed predisposed differentiated/memory T cell traits with increased activation and proliferation upon… Show more
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