Thymidine kinase 1 appears to be a marker for the prognosis of hepatocellular carcinoma based on a large-scale, multicenter study

Jiang, Yi; Guo, Lu; Han, Li; Li, Han; Li, Changlun; Wen, Lianbin; Song, Yanqiong; Wang, Zhaoyang; Wang, Pan; Guo, Qulian; Zhao, Wenjing; Liu, M F; Chen, Jiali; Wu, Zhenying; Yan, Yong; Xu, Ke; Gu, Tao; Wu, Xue; He, Kun; Su, Ke; Han, Yunwei

doi:10.1007/s00432-023-05089-z

Cited by 4 publications

(1 citation statement)

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“…Elevated TK1 levels can be detected in both hematologic malignancies and solid tumors 16 . TK1 has been proved to be a new biomarker in several cancers, including hepatocellular carcinoma 17 , prostate cancer 18 , melanoma 19 , and breast cancer 20 et al In addition, TK1 combined with HE4 and CA125 showed a better diagnostic performance in ovarian cancer 21 , 22 . Serum TK1 can act as a novel biomarker in patients with HR(+)/HER2(−) advanced breast cancer 23 .…”

Section: Discussionmentioning

confidence: 99%

A comprehensive analysis and experimental validation of TK1 in uterine corpus endometrial carcinoma

Sun,

Zhang,

Wang

et al. 2024

Sci Rep

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Uterine corpus endometrial carcinoma (UCEC) is becoming a main malignant cancer that threaten to women's health. Thymidine kinase 1 (TK1) is considering to be associated with tumorigenesis and development. Nevertheless, the function of TK1 in UCEC is still unclear. Herein, we analyzed the TK1 expression level in pan-cancer and found that TK1 was upregulated in a variety of cancers including UCEC. Patients of UCEC with high expression of TK1 were related to poor outcome. TK1 was also related to clinical stage, histologic grade and lymph node metastasis. Abnormal expression of TK1 in UCEC was related to promoter methylation while gene mutation was not frequent. TK1 and its associated genes appeared to be prominent in cell cycle and DNA replication, according to GO and KEGG analysis. Analysis of immune infiltration revealed a negative correlation between TK1 and CD8 + T cells, macrophages, and dendritic cells. In vitro experiments, TK1 knockdown resulted in the inhibition of proliferation, migration, invasion and EMT in UCEC cell lines.

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