1990
DOI: 10.1016/0277-5379(90)90093-9
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Thymidine labelling index as prognostic factor in resected non-small cell lung cancer

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Cited by 24 publications
(8 citation statements)
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“…In particular, the independence of P53 expression and cell proliferation, as observed for other tumour types (Silvestrini et al, 1993;Costa et al, 1995), supports the hypothesis that P53 has other biological functions in addition to cell -cycle regulation. Moreover, except for a relation between cell proliferation and histology, such biological variables were independent of pathological characteristics, in agreement with previous data (Kerr et al, 1983;Alama et al, 1990;Isobe et al, 1990;Miyamoto et al, 1991;Silvestrini et al, 1991;Filderman et al, 1992;Quinlan et al, 1992;M0rkve et al, 1993;Scagliotti et al, 1993;Ebina et al, 1994;Passlick et al, 1994).…”
Section: Discussionsupporting
confidence: 91%
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“…In particular, the independence of P53 expression and cell proliferation, as observed for other tumour types (Silvestrini et al, 1993;Costa et al, 1995), supports the hypothesis that P53 has other biological functions in addition to cell -cycle regulation. Moreover, except for a relation between cell proliferation and histology, such biological variables were independent of pathological characteristics, in agreement with previous data (Kerr et al, 1983;Alama et al, 1990;Isobe et al, 1990;Miyamoto et al, 1991;Silvestrini et al, 1991;Filderman et al, 1992;Quinlan et al, 1992;M0rkve et al, 1993;Scagliotti et al, 1993;Ebina et al, 1994;Passlick et al, 1994).…”
Section: Discussionsupporting
confidence: 91%
“…In particular, [3H]dT LI, an indicator of the fraction of cells actively synthesising DNA, has been demonstrated to be a predictor of prognosis in stage I NSCLC (Alama et al, 1990;Silvestrini et al, 1991). In the present study on stage II-IIIa NSCLC, we showed that [3H]dT LI has an additive prognostic role in adenocarcinomas but not in squamous cell carcinomas.…”
Section: Discussionsupporting
confidence: 48%
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“…On multivariate analysis of 89 nonsmall cell lung cancer patients who underwent complete surgery, a twofold increase in the risk of death was reported in the group of patients with a thymidine labelling index greater than the overall median thymidine labelling index of 2.9 (p=0.057) [63].…”
Section: Tumour Proliferation and Dna Contentmentioning
confidence: 99%
“…The sets of imaging data were provided for two time instants-before and after the completion of the treatment. Owing to non-availability of proliferation indexes and data that could allow us to estimate the tumour growth rate in a patient-specific manner, an extensive literature review has provided biologically reasonable values for critical tumour dynamics features, such as tumour doubling time and growth fraction [19][20][21][22][23][24]. The latter has been exploited in order to achieve an initial quantitative adaptation of the model to clinical reality.…”
Section: Mesoscopic -Macroscopic Cellular and Higher Level Tumour Dynmentioning
confidence: 99%