Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy

Link, K. H.; Kornmann, Marko; Butzer, Urwe; Leder, Gerhard; Sunelaitis, E.; Pillasch, Jürgen; Salonga, Dennis; Danenberg, Kathleen D.; Danenberg, Peter V.; Beger, H. G.

doi:10.1002/1097-0142(20000715)89:2<288::aid-cncr13>3.3.co;2-f

Cited by 2 publications

(5 citation statements)

References 11 publications

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“…Thus, theoretically, a high amount of TS or DPD in the tumor tissue is expected to be associated with a low probability of response to 5-FU and poor prognosis. In line with this theory, a considerable number of retrospective clinical studies have shown that high levels of TS and/or DPD mRNA expression are associated with a low probability of response to 5-FU in several cancers [4,8,18,19], including head and neck [20,21]. However, there was no significant correlation between mRNA expression levels of these genes and response to 5-FU.…”

Section: Discussionmentioning

confidence: 99%

“…Thymidylate synthase (TS) is the target enzyme of the antimetabolite 5-FU [4]. Dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT), and thymidine phosphorytlase (TP), are critical enzymes actively involved in 5-FU metabolism [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Previous clinical studies have indicated that intratumoral levels of TS, DPD, TP, and OPRT gene expression may predict the clinical response of several cancers to 5-FU-based chemotherapy [4,5,7]. The relative expression levels of these genes have also been reported to predict survival of patients with advanced diseases [4,8].…”

Section: Introductionmentioning

confidence: 99%

“…The relative expression levels of these genes have also been reported to predict survival of patients with advanced diseases [4,8].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Thymidine phosphorylase mRNA level predicts survival of patients with advanced oropharyngeal cancer

Ijuin

Nibu

Doi

et al. 2007

Acta Oto-Laryngologica

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By Spearman's correlation analysis, significant correlation was observed between TS and TP (gamma=0.51, p=0.018). While no correlation was observed between the tumor regression and expression of any of the genes investigated, significant association was observed between prognosis and mRNA expression levels of TS and TP. Multivariate Cox regression analysis revealed that TP mRNA expression level is a significant factor predicting prognosis (hazard ratio (HR) = - 0.204, p=0.043).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The relative expression levels of these genes have also been reported to predict survival of patients with advanced diseases [4,8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Thymidine phosphorylase mRNA level predicts survival of patients with advanced oropharyngeal cancer

Ijuin

Nibu

Doi

et al. 2007

Acta Oto-Laryngologica

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“…Thymidylate synthase, the target enzyme of fluorouracilbased chemotherapy, has commonly been reported to correlate with response and survival following resection of primary colorectal cancer [80][81][82][83]. Other studies have shown that quantitation of thymidylate synthase expression predicts clinical outcome following treatment with fluorouracil-based chemotherapy [84] and correlates with response to hepatic arterial floxuridine [85,86]. More recently, Gonen et al [38] reported that thymidylate synthase expression in hepatic tumors was a predictor of survival and progression in patients with resectable metastatic colorectal cancer.…”

Section: Tritiated Thymidine Uptake and Thymidylate Synthasementioning

confidence: 99%

Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastases

Pawlik¹,

Choti

2007

Curr Oncol Rep

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Following resection of hepatic colorectal metastases, there are few criteria for predicting which patients have more aggressive disease and are, therefore, more likely to experience recurrence and reduced survival. Traditionally, primary tumor stage, preoperative carcinoembryonic antigen level, time from primary tumor treatment to diagnosis of hepatic metastases (disease-free interval), hepatic tumor size, number of hepatic metastases, and presence of extrahepatic disease have been reported to be predictors of survival after resection. However, the data regarding the prognostic importance of these clinicopathologic factors are inconsistent and conflicting. Therefore, conventional clinicopathologic factors may be inadequate for the purposes of prognostication. More recently, there has been increased interest in identifying biologic indicators that may help better define patients at risk for recurrence after hepatic resection for colorectal metastases. Recent studies have shown that proliferation markers such as p53 expression, tritiated thymidine uptake, thymidylate synthase, Ki-67, and human telomerase reverse transcriptase may be better predictors of outcome after resection of hepatic colorectal metastases. Moreover, tumor response to preoperative chemotherapy may also prove to be a useful predictor of outcome following liver resection for colorectal metastases.

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Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy

Cited by 2 publications

References 11 publications

Thymidine phosphorylase mRNA level predicts survival of patients with advanced oropharyngeal cancer

Thymidine phosphorylase mRNA level predicts survival of patients with advanced oropharyngeal cancer

Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastases

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