Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage

Nasadyuk, C. M.; Sklyarov, Alexander

doi:10.1016/j.regpep.2012.11.004

Cited by 15 publications

(34 citation statements)

References 17 publications

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“…Peptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5]. This mediates the necessity of the effective gastroprotective measures in patients, who are at risk of gastric ulceration, in particular chronic NSAIDs users.…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays for this purpose proton pump inhibitors and H 2 -antagonists are commonly used, but due to side effects of these drugs the search for new compounds with gastroprotective properties, suitable for longterm use, remains actual [1,2]. Contemporary literature gives accumulating evidence that a number of oligopeptides play an important role in the regulation of the function of gastrointestinal tract and their synthetic analogues were reported to be effective in the prevention and treatment of gastric ulceration [1,[5][6][7][8][9][10][11][12].That is why the purpose of this review was to summarize the current data on the oligopeptides with documented gastroprotective properties and their possible mechanisms of action. …”

mentioning

confidence: 99%

“…Thymohexin possesses a very broad biological effect: stimulates the proliferation and maturation of T-lymphocytes, increases the fagocytic activity of polymorphonuclear granulocytes and macrophages, increases antibody production, modulates the activity of ATP-dependent transporting proteins of biomembranes [8]. Thymohexin also has significant antioxidant and antiinflammatory effects [1,8,37,47]. The latter are mediated by its inhibiting influence on the production of TNF-α and some other proinflammatory cytokins [1,8,37,47].…”

mentioning

confidence: 99%

“…Thymohexin also has significant antioxidant and antiinflammatory effects [1,8,37,47]. The latter are mediated by its inhibiting influence on the production of TNF-α and some other proinflammatory cytokins [1,8,37,47].Administration of thymohexin to the patients suffering from ulcerative and inflammatory diseases of the gastrointestinal tract has been found to improve significantly the treatment outcome [1,8,37]. It has been documented that administration of thymohexin caused 1.6-fold reduction of the period of healing of the mucosal defects, had positive effect on the cytokine regulation, enhanced the normalization of peripheral blood and immunologic reactivity parameters, decreased 1.5-fold the number of relapses, 2-fold decreased the quantity of urgent operations and mortality [37].…”

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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IntroductionPeptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5]. This mediates the necessity of the effective gastroprotective measures in patients, who are at risk of gastric ulceration, in particular chronic NSAIDs users. Nowadays for this purpose proton pump inhibitors and H 2 -antagonists are commonly used, but due to side effects of these drugs the search for new compounds with gastroprotective properties, suitable for longterm use, remains actual [1,2]. Contemporary literature gives accumulating evidence that a number of oligopeptides play an important role in the regulation of the function of gastrointestinal tract and their synthetic analogues were reported to be effective in the prevention and treatment of gastric ulceration [1,[5][6][7][8][9][10][11][12].That is why the purpose of this review was to summarize the current data on the oligopeptides with documented gastroprotective properties and their possible mechanisms of action. DiscussionDue to the modern outlook, regulatory peptides are considered to be phylogenetically the oldest form of bioregulation [13][14][15][16][17][18][19][20][21]. Thus, the mechanisms of peptidergic regulation of homeostasis open huge perspectives for the creation of the essentially new methods for the prevention and treatment of different diseases [13][14][15][16]. Interestingly, deep studies of the mechanisms of action of regulatory peptides showed that in many cases life-sustaining processes are regulated not by the total peptide molecules but their short-chained derivatives -oligopeptides that are produced in the course of limited proteolysis from proteins-precursors (cytokines, thymic peptides, immunoglobulins) [13,14,18,20,21].The term "oligopeptide" refers to proteins, composed of not more than 20 amino acid residues [22]. For example, it was shown that the inhibition of pancreatic juice secretion by 28-amino acidscontaining hormone ghrelin is realized by its biologically active part -pentapeptide with the sequence of amino acids Gly-Ser-Ser (n-octanoyl)-Phe [23].The advantages of the short peptides above their long-chain derivatives are high biological activity, that often many fold exceeds the activity of the peptide-precursor, high tissue specificity, lack of species specificity and lack of immunogenicity [13,14,[15][16][17][18]20,21]. It was established that low-weighing oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels [13][14][15][16][17][18][19][20][21]. The interaction with DNA was proposed to be the key moment of the realization of the biological effect of the short peptides [17][18][19]21]. This concept is s...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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Protective effect of Holothurian intestine against indomethacin induced gastric mucosal damage in rats

Qiao

Zhang

et al. 2017

J. Ocean Univ. China

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The Evaluation of the Effect of Vitamin E on Nitroso-Oxidative Processes in Mucous Membranes of the Digestive Organs Under the Conditions of Cyclooxygenase Blockage on the Background of the Low Intensity X-Ray Irradiation

Ilnytska

Datsyuk

Sklyarov

2018

MCCh

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Introduction. The simultaneous effect of several ulcerogenic factors, different due to their mechanism of action on the mucous membranes of the digestive organs needs deep elucidation. The studies were focused on the combined effect of the low intensity X-ray irradiation and cyclooxygenase blockage. It is important to evaluate the antioxidant effect of vitamin E under the conditions of simultaneous effect of different pro-inflammatory factors, acting on the nitroso-oxidative processes. The aim of the study – to investigate the effect of vitamin E on nitroso-oxidative processes in the mucous membranes of the digestive organs under the action of the low intensity X-ray irradiation and COX blockage. Research Methods. In the homogenates of the mucous membranes of stomach, small and large intestine in rats (n=64) the activity of NO-synthase, arginase, myeloperoxidase, superoxide dismutase, catalase, TBA-active products,nitrite-anioncontent and sum of nitrites and nitrates were determined. Results and Discussion. It was established that the effect of vitamin E on the background of the low intensity X-ray irradiation resulted in the decrease of iNOSactivity level (р<0.05) and nitrite-anion content (р<0.05) and increase of catalase and MPO activity in the mucous membranes of the digestive organs compared to indices obtained under the conditions of X-ray irradiation. Blockage of COX activity by indometacin on the background of the introduction of vitamin E and simultaneous effect of the low intensity X-ray irradiation revealed the peculiarities of antioxidant action of vitamin E in the mucous membranes of the digestive organs. Conclusions.Under the conditions of COX blockage on the background of the low intensity X-ray irradiation the level of lipid peroxidation processes increased, iNOSand сNOS activity decreased compared to indices under the independent effect of irradiation, whereas compared to data under the effect of indometacin lipid peroxidation processes and iNOS activity decreased. Vitamin E exerts antioxidant effect under the conditions of ulcerative action of indometacin on the background of the X-ray irradiation.

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Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage

Cited by 15 publications

References 17 publications

Gastroprotective Oligopeptides

Gastroprotective Oligopeptides

Protective effect of Holothurian intestine against indomethacin induced gastric mucosal damage in rats

The Evaluation of the Effect of Vitamin E on Nitroso-Oxidative Processes in Mucous Membranes of the Digestive Organs Under the Conditions of Cyclooxygenase Blockage on the Background of the Low Intensity X-Ray Irradiation

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