Thymol derivatives from essential oil of Doronicum corsicum L.

Antinociceptive effect of extracts and compounds from Hofmeisteria schaffneri

“…The remaining products 4-13 and 15-16 were yellow oils and the yields were 46,61,50,41,48,65,41,35,62,71,45 and 52%, respectively. The spectral properties of compounds 4-8, 12, 15, and 16 were identical to those previously described (Mathela et al, 2008;Martinez et al, 1988;Paolini et al, 2005Paolini et al, , 2007Schmitz et al, 1979;Rice and Coats, 1994;Viana et al, 1981;Ateeque et al, 2002;Sheng et al, 1984;Kumar et al, 2008, respectively). Compounds 9, 10, 11 and 13 were new chemical entities therefore their NMR (Table 1) and other spectral data are presented in this paper.…”

“…The NMR spectra (Table 1) were very similar to those of the other thymyl esters under study with the aromatic region displaying the characteristic ABX system of the trisubstituted benzene ring of thymol (Table 1). The spectra differed only in the resonances due to the acid residues which were easily assigned to a tiglic, 2-methylvaleric, 3-methylvaleric, 4-methylvaleric and hexanic acids, respectively by comparison with the information previously reported for similar structures (Mathela et al, 2008;Martinez et al, 1988;Paolini et al, 2005Paolini et al, , 2007Schmitz et al, 1979;Rice and Coats, 1994;Viana et al, 1981;Ateeque et al, 2002;Sheng et al, 1984;Kumar et al, 2008).…”

“…The resulting esters were then evaluated in the same pharmacological model. Compounds 9, 10, 11 and 13 are new chemicals entities but compounds 6 (Paolini et al, 2005), 7 (Schmitz et al, 1979;Paolini et al, 2007), 8 (Rice and Coats, 1994;Ateeque et al, 2002), 12 and 14 (Viana et al, 1981;Ateeque et al, 2002), 15 (Sheng et al, 1984), 16 (Kumar et al, 2008) and 17 (Viana et al, 1981;Ateeque et al, 2002) have been reported as natural or synthetic products and their spectral data are in agreement with those previously described. Compounds 9-11 and 13 were identified by spectral means.…”

Sandalwood Fragrance Biosynthesis Involves Sesquiterpene Synthases of Both the Terpene Synthase (TPS)-a and TPS-b Subfamilies, including Santalene Synthases

“…Monoterpene identification was aided through an in-house standard collection. All mass spectra were compared with the NIST 2005 library and the literature (17)(18)(19)(20)(21)(22)(23). The Kovat retention indices (KIs) were determined for all compounds (supplemental Figs.…”

Synthesis, Antimicrobial Activity and in silico Studies on Thymol Esters

“…The conversion of the other carboxylic acids to acyl chlorides 37,38 and the preparation of thymyl esters utilized methods from the literature. 39,40 Scheme 1 presents the synthesis of thymyl esters.…”