Thymol inhibits bladder cancer cell proliferation via inducing cell cycle arrest and apoptosis

Li, Yi; Wen, Jiaming; Du, Chun‐Hui; Hu, Su‐Min; Chen, Jiaxi; Zhang, Shigeng; Zhang, Nan; Gao, Feng; Li, Shao-jiang; Mao, Xia-Wa; Miyamoto, Hiroshi; Ding, Kefeng

doi:10.1016/j.bbrc.2017.04.009

Cited by 80 publications

(55 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several monoterpenes including linalool were reported to act as antiproliferative agents against cancer cells by inducing cell growth arrest, both at G0/G1 [21,29] or G2/M [22,30]. In our study, linalool promoted a time and dose-dependent inhibition of cell growth, as indicated by the WST-1 assay.…”

Section: Discussionsupporting

confidence: 61%

Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 61%

Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Furthermore, a high concentration of aristolochic acid, extracted from species of Aristolochia , induced cell death, partly via apoptosis, activated via increased ROS production [ 156 ]. In addition, dioscin, a natural steroid saponin, and thymol, a phenolic compound, triggered ROS-induced apoptosis in T24 bladder cancer cells [ 157 ].…”

Section: Apoptosis and Rosmentioning

confidence: 99%

A Mini-Review of Reactive Oxygen Species in Urological Cancer: Correlation with NADPH Oxidases, Angiogenesis, and Apoptosis

Miyata

Matsuo

Sagara

et al. 2017

IJMS

View full text Add to dashboard Cite

Oxidative stress refers to elevated reactive oxygen species (ROS) levels, and NADPH oxidases (NOXs), which are one of the most important sources of ROS. Oxidative stress plays important roles in the etiologies, pathological mechanisms, and treatment strategies of vascular diseases. Additionally, oxidative stress affects mechanisms of carcinogenesis, tumor growth, and prognosis in malignancies. Nearly all solid tumors show stimulation of neo-vascularity, termed angiogenesis, which is closely associated with malignant aggressiveness. Thus, cancers can be seen as a type of vascular disease. Oxidative stress-induced functions are regulated by complex endogenous mechanisms and exogenous factors, such as medication and diet. Although understanding these regulatory mechanisms is important for improving the prognosis of urothelial cancer, it is not sufficient, because there are controversial and conflicting opinions. Therefore, we believe that this knowledge is essential to discuss observations and treatment strategies in urothelial cancer. In this review, we describe the relationships between members of the NOX family and tumorigenesis, tumor growth, and pathological mechanisms in urological cancers including prostate cancer, renal cell carcinoma, and urothelial cancer. In addition, we introduce natural compounds and chemical agents that are associated with ROS-induced angiogenesis or apoptosis.

show abstract

“…The majority of terpenoids also possess pharmacological properties, including anti-cancer, anti-inflammatory, anti-viral, and anti-fungal activities [31, 32]. Several studies have shown that terpenoids show anti-cancer activity via MAPK phosphorylation, including ERK and p38, in various cancers [33–35]. In this study, physalin A increased the expression of detoxification enzymes by activating the Nrf2 pathway via ERK and p38.…”

Section: Discussionmentioning

confidence: 61%

Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes

Shin

Lee

et al. 2019

BMC Complement Altern Med

View full text Add to dashboard Cite

Background Physalin A isolated from Physalis alkekengi var. franchetii has been known to have many pharmacological properties. However, its effect through the Nrf2 pathway has not yet been elucidated. In the present study, we determined the effects of physalin A on cancer chemoprevention via the Nrf2 pathway. Methods Experiments were performed in Hepa-1c1c7 and HepG2 cells. The quinone reductase (QR) activity assay was used to assess the activity of physalin A and other compounds isolated from P. alkekengi . The antioxidant response element (ARE) reporter assay was used to determine physalin A induced transcription of Nrf2 target genes, whereas the oligonucleotide pull-down assay was used to investigate Nrf2 binding to the AREs post physalin A treatment. Real-time PCR and western blotting were performed to determine the expression of Nrf2 target genes. Immunocytochemistry was used to determine Nrf2 localization after treatment with physalin A. Kinase inhibitors were used to test the involvement of Nrf2-targeting kinases and the role of ERK and p38 phosphorylation was confirmed using western blotting. Results Physalin A significantly induced QR activity. As an upstream effector of QR, Nrf2 induced genes containing the ARE, which encode various antioxidants and detoxification enzymes. We observed that physalin A increased the expression of Nrf2 and its target genes in HepG2 cells. Moreover, we observed that physalin A-induced Nrf2 activation was regulated by ERK and p38 kinase in HepG2 cells. Conclusions Taken together, we showed that physalin A increased detoxifying enzyme expression via activation of Nrf2 and its target genes. These results imply that physalin A could be a potential chemopreventive agent for liver diseases, as well as cancer.

show abstract

Thymol inhibits bladder cancer cell proliferation via inducing cell cycle arrest and apoptosis

Cited by 80 publications

References 28 publications

Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways

Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways

A Mini-Review of Reactive Oxygen Species in Urological Cancer: Correlation with NADPH Oxidases, Angiogenesis, and Apoptosis

Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes

Contact Info

Product

Resources

About