Thymoma-associated multiorgan autoimmunity initially manifested by graft-versus-host disease–like erythroderma: Case report and possible therapeutic role of antimalarial drugs

Hile, Grace A.; Novice, Taylor; Kochkodan, Jeanne; Chan, May P.; Guðjónsson, Jóhann E.; Eshaq, Milad

doi:10.1016/j.jdcr.2020.06.007

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…It is often associated with paraneoplastic or autoimmune diseases such as myasthenia gravis [20]. However, our patient never carried any autoimmune disease diagnosis, and there were no apparent inciting stressors identified that may have triggered his condition.…”

Section: Discussionmentioning

confidence: 65%

Primary Refractory Catastrophic Antiphospholipid Syndrome Masquerading as Buerger’s Disease

Tannous

Rosso

Iannuccilli

et al. 2021

Cureus

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Catastrophic antiphospholipid syndrome (CAPS) is a lethal disease with up to 30% mortality rate. It can occur as a primary disease or secondary to an underlying autoimmune disease. Current treatment focuses on disease control with anticoagulation and steroids. Plasma exchange and intravenous immunoglobulin (IVIG) have shown some benefit when added. Monoclonal drugs such as rituximab have shown some benefit in refractory cases, and eculizumab, a drug approved for use in atypical hemolytic uremic syndrome, has demonstrated disease control in a few case reports. We describe a unique case of primary refractory CAPS with an unusual presentation that was treated with five lines of therapy before disease control was established.

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Section: Discussionmentioning

confidence: 65%

Primary Refractory Catastrophic Antiphospholipid Syndrome Masquerading as Buerger’s Disease

Tannous

Rosso

Iannuccilli

et al. 2021

Cureus

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“…Another patient with PRCA and myasthenia gravis developed TAMA and received cyclosporine 175 mg twice daily and prednisolone (40 mg/day). Although his skin improved, he died of multiple organ failure secondary to pneumonia [ 10 ]. From these reports, even when two of PRCA, GS, and TAMA are combined, a fatal infection may develop.…”

Section: Discussionmentioning

confidence: 99%

A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity

Nakagawa

Matsumoto

Yamamoto

et al. 2022

Respiratory Medicine Case Reports

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“…3 The disease was first named and described in 2007, by Wadhera et al 2 Since then, few cases of TAMA have been documented and clinicopathological features are beginning to be elucidated. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Here, we add to the literature by presenting a case of severe skin reaction in the setting of TAMA and to provide a brief review of these features.…”

Section: Discussionmentioning

confidence: 99%

Thymoma-associated multiorgan autoimmunity with cutaneous only presentation: A case report

Bendayan

Mititelu

Redpath

et al. 2021

SAGE Open Medical Case Reports

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Thymoma-associated multiorgan autoimmunity disease can be seen in patients with thymomas and presents with features of graft versus host disease. Here, we report a case of a 52-year-old woman with a complex medical history including malignant thymoma, myasthenia gravis, Good’s syndrome, and T cell large granular lymphocytic leukemia who presented with a diffuse pruritic rash ultimately found to be compatible with a cutaneous presentation of thymoma-associated multiorgan autoimmunity disease. The eruption heralded the recurrence of the malignant thymoma and the rash was ultimately found to be resistant to a multitude of therapies except for oral corticosteroids.

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Thymoma-associated multiorgan autoimmunity initially manifested by graft-versus-host disease–like erythroderma: Case report and possible therapeutic role of antimalarial drugs

Cited by 9 publications

References 11 publications

Primary Refractory Catastrophic Antiphospholipid Syndrome Masquerading as Buerger’s Disease

Primary Refractory Catastrophic Antiphospholipid Syndrome Masquerading as Buerger’s Disease

A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity

Thymoma-associated multiorgan autoimmunity with cutaneous only presentation: A case report

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