Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

Ahmad, Anas; Mishra, Rakesh; Vyawahare, Akshay; Kumar, Ajay; Rehman, Muneeb U.; Qamar, Wajhul; Khan, Abdul Quaiyoom; Khan, Rehan

doi:10.1016/j.jsps.2019.09.008

Cited by 122 publications

(81 citation statements)

References 102 publications

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“…In thermogravimetric analysis the thermal decomposition of TQ initiates at 65 °C and ends at 213 °C. Previous studies have reported that TQ is a member of the monoterpene class of natural complexes and displays keto-enol tautomerism [ 56 ]. Specifically, the keto configuration is the main arrangement involved in the therapeutic effects of TQ [ 57 ].…”

Section: Nigella Sativa and Thymoquinone As Thementioning

confidence: 99%

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

2020

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Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory, antihypertensive, hypoglycemic, antiparasitic and anti-asthmatic effects. Several studies have examined the pharmacological actions of TQ in the treatment of oral diseases but its potential role in periodontal therapy and regeneration is not yet fully defined. The present investigation has been designed to review the scientific studies about the effects of TQ as an adjunct to periodontal treatment to promote healing and periodontal regeneration. Along with clinical experiments, in vitro studies exhibit the beneficial effects of TQ during periodontal therapy. Nevertheless, additional comprehensive clinical and preclinical studies at cellular and molecular levels are essential to examine the particular action mechanisms of Nigella sativa and its elements, particularly TQ, during periodontal treatment or regeneration.

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Section: Nigella Sativa and Thymoquinone As Thementioning

confidence: 99%

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

2020

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“…A number of studies have documented the role of the pro-oxidant activity of TQ in its chemopreventive and anticancer activities [26,32]. Conversion of TQ into semiquinone is accompanied by the release of reactive oxygen species (ROS) that include superoxide, peroxide, and hydroxyl radicals.…”

Section: Pro-oxidant Role Of Tq In Chemopreventionmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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“…In addition, thymoquinone is being used for cancer treatment [36]. Ahmad et al found that thymoquinone has potential to be a chemo preventive agent in cancer studies and use in anti-tumor therapeutic paradigms [37].…”

Section: Discussionmentioning

confidence: 99%

Stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats

Turkoz¹,

Türköz²,

Önger³

et al. 2021

Turk J Med Sci

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The stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats Abstract Background/aim: This study was aimed to investigate the effects of thymoquinone, which is the essential bioactive component of the volatile oil of Nigella sativa on the peridural fibrosis in rats following laminectomy. Materials and methods: Twenty female Wistar Albino rats were used in our study. The rats were randomly divided into two groups as Sham and Surgery+Thymoquinone. Both groups underwent laminectomy at L1, under general anesthesia. The sham group was not subjected to any drug application. The second group was treated with intraperitoneal 10 mg/kg thymoquinone per day for a period of 28 days, following the same surgical procedure. All the groups were sacrificed after four weeks and the laminectomy area was examined in terms of new bone volume, capillary volume and fibrosis volume using stereological approaches. Results: Statistically significant differences were found between the Sham and Surgery+Thymoquinone groups, in terms of the new bone volume (p=0.01), capillary volume (p=0.01) and fibrosis volume (p<0.001). It was noted that thymoquinone caused significant increase in the new bone volume and vascular volume and a significant decrease in the fibrosis volume. Conclusion: The results of our study indicate that thymoquinone is effective in decreasing the peridural fibrosis when applied on laminectomy model.

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Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

Abstract: Graphical abstract

Cited by 122 publications

References 102 publications

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats

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