Thymoquinone ameliorates age-related hearing loss in C57BL/6J mice by modulating Sirt1 activity and Bak1 expression

Salam, Sherine Abdel; Mostafa, Fatma; Alnamshan, Mashael M.; Elshewemi, Salma S.; Sorour, Jehan

doi:10.1016/j.biopha.2021.112149

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2022

2025

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Cited by 7 publications

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“…It is known for its ability to balance oxidation/antioxidation and reduce mitochondrial damage, DNA damage and apoptosis ( Chen C. et al, 2020 ). It has been found to play a non-negligible role in ARHL ( Salam et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Potential therapeutic role of SIRT1 in age- related hearing loss

Zhao

Tian²

2022

Front. Mol. Neurosci.

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Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1), known as a regulator of the cell cycle, the balance of oxidation/antioxidant and mitochondrial function, has been proven to have anti-aging and life-extending effects, and its possible connection with ARHL has received increasing attention in recent years. This paper provides an overview of research on the connection between SIRT1 and ARHL. Topics cover both the functions of SIRT1 and its important role in ARHL. This review concludes with a look at possible research directions for ARHL in the future.

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Section: Introductionmentioning

confidence: 99%