Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats

El-Saleh, S. C.; Al-Sagair, Othman A.; Alkhalaf, Maha I.

doi:10.1016/s0167-5273(03)00108-6

Cited by 59 publications

(24 citation statements)

References 35 publications

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“…This indicates that the feeding of nigella seed oil diets to broiler chicks had a non-toxic effect on the liver and kidneys, and did not alter liver enzyme activity. This conforms with the results of El- Saleh et al (2004), who found a decrease in AST and ALT activity from feeding broilers nigella seed. The increase in GSH-Px activity may be because nigella seed oil is known to possess strong antioxidant activities (El-Dakhakhny et al, 2002a;Mahmoud et al, 2002).…”

Section: Discussionsupporting

confidence: 92%

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Saleh¹

2014

SA J. An. Sci.

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This study was conducted to study the effect of nigella seed oil as an alternative to the antibiotic, avilamycin, on growth, digestibility, muscle fatty acid profile and some physiological parameters in broiler chickens. Fifty four chicks at 15 d of age (average weight, 320 ± 3 g) were divided into a control group and two treatment groups (n = 18). The control group was fed a basal diet and the experimental treatment groups were fed the basal diet supplemented with avilamycin at a level of 0.001% or nigella seed oil at 1 mL/kg. Growth performance and breast muscle fatty acid profile were measured. Although feed intake was not affected, bodyweight gain was increased, and thus feed conversion ratio was improved by feeding nigella seed oil compared with the control and avilamycin groups. Plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations were higher, while, plasma high-density lipoprotein cholesterol (HDL-C) acid level was lower and polyunsaturated fatty acid levels were higher in the muscle fat of birds receiving nigella seed oil than those receiving the other treatments. It is concluded that feeding nigella seed oil as alternative to avilamycin antibiotic improved growth performance, modified the fatty acids profile in muscles and enhances plasma total cholesterol, LDL and HDL concentrations, and glutathione peroxidase (GSH-Px) activity.

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Section: Discussionsupporting

confidence: 92%

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Saleh¹

2014

SA J. An. Sci.

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“…They have reported that NSO elevated the level of GPX in pentylenetetrazol kindling seizures in mice compared to an untreated group. Oral administration of NSO (at 100 mg/kg body weight for 1 week) resulted in significantly increased levels of total antioxidant status in methionineinduced hyperhomocysteinemia in rats 58 .…”

Section: Anti-oxidant Anti-inflammatory and Immunomodulatory Effectsmentioning

confidence: 92%

“…It may be due to calcium channel inhibitory or an opening effect for NS on potassium channels of the isolated heart 168 . NS had smooth muscle relaxant 69 and ameliorative effect of endothelial dysfunction 58 . It seems that the most important mechanisms involved in vasorelaxation of NS extract are inhibition of extracellular Ca 2+ influx, blockade of KATP channels, also suppression of IP3-mediated receptors 169 .…”

Section: Gastroprotective Effectsmentioning

confidence: 94%

Untitled

2015

IJPSR

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“…Nigella sativa (NS), family Ranunculaceae, has pharmaceutical and medical properties such as diuretics, antihypertensive, antibacterial, anthelmintic, antioxidant, anti-inflammatory, and immunopotential activity. [1][2][3][4] Many studies pointed on the effect of NS extracts on the immune system. All of them have shown that the NS extracts inhibit many inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

Effect of gum arabic and Nigella sativa on T-helper1 and T-helper2 immune response in Wistar rats infected with methicillin-resistant Staphylococcus aureus

Abd-El-Hafez¹,

Ismael²,

Soliman³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background:The herbal medications are widely used in folk medicine for treatment of variable diseases and infection. Staphylococcus aureus (Sa) is a Gram-positive bacteria that cause severe organ affection, especially in the lung. Nigella sativa (NS) and gum arabic (GA) are probiotics with multi-beneficial effects for human health. Aims and Objectives: The current study was outlined to examine the protective effect of NS and GA against SA induced serum alterations and changes in cytokines and antioxidants expressions. Materials and Methods: A total of 42 male Wistar rats were allocated into six groups (6 each). Control group without any treatment; SA group in a dose of 2 × 10 9 colony forming units /mL per rat. Rats in 3-6 groups served as SA infected groups and received NS for Group 3 (150 mg/kg b.w. daily), GA plus SA for Group 4 (10% wt/vol. daily), and SA group received a mixture of NS plus GA for Group 5, and SA administered group received Lactobacillus for Group 6 as a positive control. NS and GA were administered 2 weeks before SA infection and continued for 1 week. Serum levels of cytokines and oxidative stress biomarkers were measured. Lung tissues were examined at molecular levels for mRNA expression of inflammatory cytokines and antioxidants. Results: SA induced a significant decrease in serum levels of interleukin -6 (IL-6), IL-2, and tumor necrosis factor -alpha. NS induced significant decrease on examined cytokines levels in SA (P < 0.05). GA did not induce any additive changes in cytokines. When both NA and GA were administered together, NS induced additive inhibitory effect. SA injection induced significant increase in serum levels of catalase and glutathione reductase. NS induced additive significant increase on antioxidant levels in SA injected. GA did not induce any additive increase for examined antioxidant levels. NS decreased total bacterial count increased in SA group more significantly than the effect induced by NS. Conclusion: NS has the potential to control the degree of inflammation at the protein and gene levels of examined cytokines (T-helper1/T-helper2) and antioxidants compared to the effect induced by GA.

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Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats

Cited by 59 publications

References 35 publications

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Nigella seed oil as alternative to avilamycin antibiotic in broiler chicken diets

Untitled

Effect of gum arabic and Nigella sativa on T-helper1 and T-helper2 immune response in Wistar rats infected with methicillin-resistant Staphylococcus aureus

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