Thymoquinone attenuates hepatotoxicity and oxidative damage caused by diazinon: an in vivo study

Nili‐Ahmadabadi, Amir; Alibolandi, Parisa; Ranjbar, Akram; Mousavi, Leila; Nili-Ahmadabadi, Hossein; Larki‐Harchegani, Amir; Ahmadimoghaddam, Davoud; Omidifar, Navid

doi:10.4103/1735-5362.245962

Cited by 47 publications

(36 citation statements)

References 28 publications

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“…e optimum protective effect was observed at the dose of 200 mg/kg of the extract. In the present study, increased hepatic serum enzymes (ALT, AST, and ALP) are considered as an important biomarker in the diagnosis of liver failure [26]. erefore, the results of the current study indicate disruption of hepatic cells' integrity caused by Cd and occurrence of hepatic failure.…”

Section: E Effects Of a Hirtifolium Extract On Hepatic Oxidativementioning

confidence: 57%

Biochemical and Histological Evidence on the Protective Effects of Allium hirtifolium Boiss (Persian Shallot) as an Herbal Supplement in Cadmium‐Induced Hepatotoxicity

Omidifar

Nili‐Ahmadabadi

Gholami

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background and Objectives. Allium hirtifolium Boiss (Persian shallot), as an edible vegetable, has several pharmacological properties including antimicrobial, anti-inflammatory, and antioxidative effects, while its protective effects in liver cells are controversial. In this study, we examined the effect of A. hirtifolium extract on cadmium- (Cd-) induced hepatotoxicity in rats. Materials and Methods. Thirty-six male Wistar rats were divided into six groups: groups 1, 2, and 3 received vehicle, Cd (100 mg/L/day by drinking water), and A. hirtifolium extract (200 mg/kg/day; orally), respectively. Groups 4, 5, and 6 were Cd groups which were treated with A. hirtifolium extract (50, 100, and 200 mg/kg/day, respectively). After 2 weeks, liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) and also oxidative stress biomarkers including lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol molecule (TTM), and the histopathological changes were determined using standard procedure. Results. The findings showed that Cd caused a remarkable rise in levels of serum hepatic enzymes such as ALT (P<0.001), AST (P<0.01) and ALP (P<0.001) compared with the control group. In addition, Cd led to the decreasing of the levels of TTM (P<0.001) and TAC (P<0.001) and increasing of LPO (P<0.001) in liver tissue in comparison with the control group. In this regard, remarkable vascular congestion, hepatocellular degeneration, and vacuolization were observed in hepatic tissue of Cd-treated rats. Following the administration of A. hirtifolium extract, a significant improvement was observed in the functional and oxidative stress indices of hepatic tissue alongside histopathologic changes. Conclusion. The current study indicated that the A. hirtifolium extract might prevent hepatic oxidative injury by improving oxidant/antioxidant balance in rats exposed to Cd.

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Section: E Effects Of a Hirtifolium Extract On Hepatic Oxidativementioning

confidence: 57%

Biochemical and Histological Evidence on the Protective Effects of Allium hirtifolium Boiss (Persian Shallot) as an Herbal Supplement in Cadmium‐Induced Hepatotoxicity

Omidifar

Nili‐Ahmadabadi

Gholami

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…9,10 Oxidative stress is a state of an imbalance between oxidation and antioxidation involved in cellular damage. 11,12 Excessive accumulation of ROS leads to cellular injuries, such as lipid peroxidation, DNA oxidative disruption, and enzyme inactivation. 13,14 Synthetic or natural scavengers of ROS and antioxidants could attenuate ATO-induced toxicity, thereby enabling full exploitation of the therapeutic potential of ATO.…”

Section: Introductionmentioning

confidence: 99%

<p>Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats</p>

Liu

Liang

Zheng

et al. 2020

DDDT

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Arsenic trioxide (ATO) has been shown to induce hepatic injury. Crocetin is a primary constituent of saffron, which has been verified to have antioxidant and antiinflammatory effects. In the current experiment, we evaluated the efficacy of crocetin against ATO-induced hepatic injury and explored the potential molecular mechanisms in rats. Methods: Rats were pretreated with 25 or 50 mg/kg crocetin 6 h prior to treating with 5 mg/ kg ATO to induce hepatic injury daily for 7 days. Results: Treatment with crocetin attenuated ATO-induced body weight loss, decreases in food and water consumption, and improved ATO-induced hepatic pathological damage. Crocetin significantly inhibited ATO-induced alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) increases. Crocetin prevented ATO-induced liver malondialdehyde (MDA) and reactive oxygen species (ROS) levels. Crocetin abrogated the ATO-induced decrease of catalase (CAT) and superoxide dismutase (SOD) activity. Crocetin was found to significantly restore the protein levels of interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor-alpha (TNF-α). Furthermore, crocetin promoted the expression of nuclear factor erythroid 2 related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NADP(H): quinone oxidoreductase 1 (NQO1). Conclusion: These findings suggest that crocetin ameliorates ATO-induced hepatic injury in rats. In addition, the effect of crocetin might be related to its role in antioxidant stress, as an anti-inflammatory agent, and in regulating the Nrf2 signaling pathway.

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“…Oxidative stress is the outcome of an imbalance between antioxidant system and free radicals created in cellular processes (21). Since this process exerts an important role in cadmium-induced nephrotoxicity, the oxidant/ antioxidant markers such as LPO, TAC and TTM were assayed.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

Kohnepoushi

Dastan

Nili‐Ahmadabadi

2020

Avicenna J Pharm Res

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Background: Pistacia atlantica kurdica has recently been shown to possess free radical scavenging ability. The current study aims to investigate the protective effect of this plant against cadmium-induced nephrotoxicity. Methods: Thirty-six rats were divided into 6 groups (6 in each), and treated as follows: group 1 received normal saline (control group), group 2 (positive control) received cadmium by drinking water (100 mg/ L/d), group 3 received 200 mg/kg of P. atlantica extract, and groups 4-6 received cadmium as well as 50, 100 and 200 mg/kg/d of P. atlantica extract (orally), respectively. After 2 weeks, oxidative damage and renal function markers were assayed by standard methods. Results: In cadmium group, a significant increase was observed in serum blood urea nitrogen (BUN) (P<0.01) and lipid peroxidation (LPO) level of renal tissue (P<0.001) and a remarkable decrease was found in total thiol molecules (TTM) of the kidney (P<0.001). Despite the decreased renal antioxidant capacity, these changes were not significant. P. atlantica extract improved the LPO, TTM, and histopathological changes in renal tissue. Conclusion: In this study, although the P. atlantica extract did not have a significant effect on cadmiuminduced renal dysfunction, it did improve the oxidative/antioxidant balance in renal tissue.

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Thymoquinone attenuates hepatotoxicity and oxidative damage caused by diazinon: an in vivo study

Cited by 47 publications

References 28 publications

Biochemical and Histological Evidence on the Protective Effects of Allium hirtifolium Boiss (Persian Shallot) as an Herbal Supplement in Cadmium‐Induced Hepatotoxicity

Biochemical and Histological Evidence on the Protective Effects of Allium hirtifolium Boiss (Persian Shallot) as an Herbal Supplement in Cadmium‐Induced Hepatotoxicity

<p>Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats</p>

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

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