Thymoquinone-Loaded Polymeric Films and Hydrogels for Bacterial Disinfection and Wound Healing

Haq, Anika; Kumar, Suneel; Mao, Yong; Berthiaume, François; Michniak‐Kohn, Bozena

doi:10.3390/biomedicines8100386

Cited by 15 publications

(4 citation statements)

References 32 publications

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“…Typically, viscosities change from 1500 mPa to 80,000 mPa during the dissolution process of solids [106]. The influence of polymer concentration was reported by Haq et al (2020) [77]; in their study, the addition of 4% w/w HPMC revealed a reduction in elastic modulus compared with the addition of 6% w/w in a biocompatible topical polymeric film that has the potential to deliver the antibacterial agent directly to the skin to manage the local wound infection, and thereby wound healing [109]. The polymers undergo an aging process during casting, and potential increases in batch-to-batch variation are expected.…”

Section: Reproducibility Establishing Quality Control Parametersmentioning

confidence: 99%

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Borbolla-Jiménez,

Peña-Corona,

Farah

et al. 2023

Pharmaceutics

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Wound healing is a complex process that involves restoring the structure of damaged tissues through four phases: hemostasis, inflammation, proliferation, and remodeling. Wound dressings are the most common treatment used to cover wounds, reduce infection risk and the loss of physiological fluids, and enhance wound healing. Despite there being several types of wound dressings based on different materials and fabricated through various techniques, polymeric films have been widely employed due to their biocompatibility and low immunogenicity. Furthermore, they are non-invasive, easy to apply, allow gas exchange, and can be transparent. Among different methods for designing polymeric films, solvent casting represents a reliable, preferable, and highly used technique due to its easygoing and relatively low-cost procedure compared to sophisticated methods such as spin coating, microfluidic spinning, or 3D printing. Therefore, this review focuses on the polymeric dressings obtained using this technique, emphasizing the critical manufacturing factors related to pharmaceuticals, specifically discussing the formulation variables necessary to create wound dressings that demonstrate effective performance.

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Section: Reproducibility Establishing Quality Control Parametersmentioning

confidence: 99%

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Borbolla-Jiménez,

Peña-Corona,

Farah

et al. 2023

Pharmaceutics

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“…The mats composed of polyurethane loaded with Nigella sativa oil were studied to assess the in vivo wound-repairing effect (Aras et al 2021). The essential oil of Nigella sativa seeds contains thymoquinone, which was reported to have wound-healing activity (Haq et al 2020). Different studies were performed to obtain an effective wound healing process e. g. loaded thymoquinone chitosan-lecithin micelles which keep thymoquinone at the site of wounds with controlled release of the drug (Negi et al 2020).…”

Section: Wound Healing Potentials Of Various Plant Extractsmentioning

confidence: 99%

The wound healing effect of botanicals and pure natural substances used in in vivo models

El-Sherbeni

Negm

2023

Inflammopharmacol

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Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the speed of wound contraction, the proliferation of epithelial cells, and collagen formation. The need for proper management of acute wounds to be cured and not turned into chronic wounds is a significant clinical challenge. The traditional practice of medicinal plants in many regions of the world has been used in wound healing since ancient times. Recent scientific research introduced evidence of the efficacy of medicinal plants, their phyto-components, and the mechanisms underlying their wound-repairing activity. This review aims to briefly highlight the wound-curing effect of different plant extracts and purely natural substances in excision, incision, and burn experimental animal models with or without infection of mice, rats (diabetic and nondiabetic), and rabbits in the last 5 years. The in vivo studies represented reliable evidence of how powerful natural products are in healing wounds properly. They have good scavenging activity against Reactive oxygen species (ROS) and anti-inflammatory and antimicrobial effects that help in the process of wound healing. It is evident that incorporating bioactive natural products into wound dressings of bio- or synthetic polymers in nanofiber, hydrogel, film, scaffold, and sponge forms showed promising results in different phases of the wound-curing process of haemostasis, inflammation, growth, re-epithelialization, and remodelling.

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“…Transparent films enable the exchange of carbon dioxide and oxygen between the wound and the environment, while protecting the site from microbial contamination. 7 The film can be developed by spraying drug-polymer mixtures onto the skin as a patient-friendly method compared to gels and ointments. The advantages of film-forming spray over conventional topical formulations are a uniform distribution of the drug, lower irritation, improved wound healing by controlling moisture, and continuous spraying, which enhances the mechanical properties of the polymeric film.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and in vitro characterization of curcumin film-forming topical spray: An integrated approach for enhanced patient comfort and efficacy

Shetty,

Dubey,

Chrystle

et al. 2024

F1000Res

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Background Curcumin, known for its anti-inflammatory properties, was selected for the developing consumer friendly film forming spray that offers precise delivery of curcumin and and improves patient adherence. Methods An optimized film-forming solution was prepared by dissolving curcumin (1%), Eudragit RLPO (5%), propylene glycol (1%), and camphor (0.5%) in ethanol: acetone (20:80) as the solvent. The solution was filled in a spray container which contained 70% solutions and 30% petroleum gas. In-vitro characterization was performed. Results Potential anti-inflammatory phytoconstituents were extracted from the PubChem database and prepared as ligands, along with receptor molecules (nsp10-nsp16), for molecular docking using Autodock Vina. The docking study showed the lowest binding energy of -8.2 kcal/mol indicates better binding affinities. The optimized formulation consisted of ethanol:acetone (20:80) as the solvent, Eudragit RLPO (5%) as the polymer, propylene glycol (1%) as the plasticizer, and camphor oil (0.5%) as the penetration enhancer. The optimized formulation exhibited pH of 5.8 ± 0.01, low viscosity, low film formation time (19.54 ± 0.78 sec), high drug content (8.243 ± 0.43 mg/mL), and extended ex vivo drug permeation (85.08 ± 0.09%) for nine hours. Consequently, the formulation was incorporated into a container using 30% liquefied petroleum gas, delivering 0.293 ± 0.08 mL per actuation, containing 1.53 ± 0.07 mg of the drug. The film-forming spray exhibited higher cumulative drug permeation (83.94 ± 0.34%) than the marketed cream formulation and pure drug solution after 9 h, with an enhancement ratio of 14. Notably, the film-forming spray exhibited no skin irritation and remained stable for over three months. Conclusions The developed curcumin film-forming system is promising as a carrier for wound management because of its convenient administration and transport attributes. Further in vivo studies are required to validate its efficacy in wound management.

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Thymoquinone-Loaded Polymeric Films and Hydrogels for Bacterial Disinfection and Wound Healing

Cited by 15 publications

References 32 publications

Films for Wound Healing Fabricated Using a Solvent Casting Technique

Films for Wound Healing Fabricated Using a Solvent Casting Technique

The wound healing effect of botanicals and pure natural substances used in in vivo models

Fabrication and in vitro characterization of curcumin film-forming topical spray: An integrated approach for enhanced patient comfort and efficacy

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