Thymus algeriensis Bioss &amp; Reut: Relationship of phenolic compounds composition with in vitro/in vivo antioxidant and antibacterial activity

Righi, Nadjat; Boumerfeg, Sabah; Fernandes, Pedro Alexandrino; Deghima, Amirouche; Baali, Faiza; Coelho, Elisabete; Cardoso, Susana M.; Coimbra, Manuel A.; Baghiani, Abderrahmane

doi:10.1016/j.foodres.2020.109500

Cited by 33 publications

(23 citation statements)

References 69 publications

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“…To estimate the imbalance between oxidant/antioxidant status, which normally associates diabetes, malondialdehyde (MDA), the product of lipid breakdown, was selected as a valuable indicator of free radical-induced lipid peroxidation. Predictably counting on the phenolic content richness [ 59 ], both extracts were found to significantly decrease the pancreatic MDA, where Hs extracts showed the most notable antioxidant behavior ( Figure 4 e, Supplementary Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

Molecular Networking Leveraging the Secondary Metabolomes Space of Halophila stipulaceae (Forsk.) Aschers. and Thalassia hemprichii (Ehrenb. ex Solms) Asch. in Tandem with Their Chemosystematics and Antidiabetic Potentials

et al. 2021

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The Red Sea is one of the most biodiverse aquatic ecosystems. Notably, seagrasses possess a crucial ecological significance. Among them are the two taxa Halophila stipulacea (Forsk.) Aschers., and Thalassia hemprichii (Ehrenb. ex Solms) Asch., which were formally ranked together with the genus Enhalus in three separate families. Nevertheless, they have been recently classified as three subfamilies within Hydrocharitaceae. The interest of this study is to explore their metabolic profiles through ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS/MS) analysis in synergism with molecular networking and to assess their chemosystematics relationship. A total of 144 metabolites were annotated, encompassing phenolic acids, flavonoids, terpenoids, and lipids. Furthermore, three new phenolic acids; methoxy benzoic acid-O-sulphate (16), O-caffeoyl-O-hydroxyl dimethoxy benzoyl tartaric acid (26), dimethoxy benzoic acid-O-sulphate (30), a new flavanone glycoside; hexahydroxy-monomethoxy flavanone-O-glucoside (28), and a new steviol glycoside; rebaudioside-O-acetate (96) were tentatively described. Additionally, the evaluation of the antidiabetic potential of both taxa displayed an inherited higher activity of H. stipulaceae in alleviating the oxidative stress and dyslipidemia associated with diabetes. Hence, the current research significantly suggested Halophila, Thalassia, and Enhalus categorization in three different taxonomic ranks based on their intergeneric and interspecific relationship among them and supported the consideration of seagrasses in natural antidiabetic studies.

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Section: Resultsmentioning

confidence: 99%

Molecular Networking Leveraging the Secondary Metabolomes Space of Halophila stipulaceae (Forsk.) Aschers. and Thalassia hemprichii (Ehrenb. ex Solms) Asch. in Tandem with Their Chemosystematics and Antidiabetic Potentials

et al. 2021

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“…They reported that the main components were luteolin 4-glucoside, luteolin 7-glucoside and apigenin 7-glucoside and these compounds exhibited significant DPPH radical scavenging activity. The antioxidant activity of rosmarinic acid has been reported by many researchers [ 35 , 36 , 37 , 38 , 39 ]. Therefore, rosmarinic acid was considered to have a positive effect on antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antioxidant and Enzyme Inhibitory Activities of Onosma bourgaei and Onosma trachytricha and in Silico Molecular Docking Analysis of Dominant Compounds

İstifli

2021

Molecules

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The aim of this study was to investigate the chemical composition, antioxidant and enzyme inhibitory activities of methanol (MeOH) extracts from Onosma bourgaei (Boiss.) and O. trachytricha (Boiss.). In addition, the interactions between phytochemicals found in extracts in high amounts and the target enzymes in question were revealed at the molecular scale by performing in silico molecular docking simulations. While the total amount of flavonoid compounds was higher in O. bourgaei, O. trachytricha was richer in phenolics. Chromatographic analysis showed that the major compounds of the extracts were luteolin 7-glucoside, apigenin 7-glucoside and rosmarinic acid. With the exception of the ferrous ion chelating assay, O. trachytricha exhibited higher antioxidant activity than O. bourgaei. O. bourgaei exhibited also slightly higher activity on digestive enzymes. The inhibitory activities of the Onosma species on tyrosinase were almost equal. In addition, the inhibitory activities of the extracts on acetylcholinesterase (AChE) were stronger than the activity on butyrylcholinesterase (BChE). Molecular docking simulations revealed that luteolin 7-glucoside and apigenin 7-glucoside have particularly strong binding affinities against ChEs, tyrosinase, α-amylase and α-glucosidase when compared with co-crystallized inhibitors. Therefore, it was concluded that the compounds in question could act as effective inhibitors on cholinesterases, tyrosinase and digestive enzymes.

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“…From all phenolic acids ( Figure 4 ), the leaves of T. algeriensis are rich in vanillic and rosmarinic acids, well-known phenolic acids with previously confirmed biological and pharmacological activities. These two compounds were characterized in the Algerian and Tunisian plants [ 7 , 18 – 21 , 23 , 24 ]. The plant also contained phenolic acid derivatives such as rosmarinic acid glucoside, characterized in the methanolic extract of the Algerian plants [ 22 ].…”

Section: Phytochemical Composition Of T Algeriensismentioning

confidence: 99%

“…Toxicity parameters were mostly related to hepatic and renal functions, mortality, body and organ weights, and histopathological evaluation of tissues ( Table 7 ). Righi et al showed that the hydromethanolic extract of T. algeriensis aerial parts (Algeria) administrated orally to Albino male mice at 200–800 mg/kg did not influence the hepatic (AST and ALT) and renal functional markers (urea and creatine) [ 24 ]. Similarly, Guesmi et al observed no sign of toxicity or mortality after 15 days of oral administration of EO from Tunisian T. algeriensis at 180 mg/kg per day dissolved in normal saline to Sprague Dawley rats with no pathological change and normal histoarchitecture [ 118 ].…”

Section: In Vivo Pharmacological Activitiesmentioning

confidence: 99%

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

Mahdi

Bakrim

Bitchagno

et al. 2022

Oxidative Medicine and Cellular Longevity

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Growing concern for public health has increased the need to change the paradigm towards a healthcare system that advocates holistic practices while reducing adverse effects. Herbal therapy is becoming an integral part of the therapeutic arsenal, and several successful plant-derived compounds/molecules are being introduced into the market. The medicinal plants belonging to the genus Thymus are among the most important species within the Lamiaceae family. One of them is Thymus algeriensis which is mainly distributed in the Mediterranean region. For a long time, this species has been used in traditional medicine to treat several disorders and diseases including inflammation, diabetes, rheumatism, digestive, and respiratory affections. This review describes the traditional uses, phytochemical composition, and biological and pharmacological activities of T. algeriensis extracts. Data were obtained using electronic databases such as SciFindern, ScienceDirect, Scopus, and Web of Science. Several plant-based extracts and a broad spectrum of identified secondary metabolites were highlighted and discussed with respective activities and modes of action. T. algeriensis represents a promising natural resource for the pharmaceutical industry mainly for antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. Considering these findings, more research is needed to transmute the conventional uses of T. algeriensis into scientifically sound information. Moreover, extensive preclinical, clinical, toxicological, and pharmacokinetic trials on this species and its derivatives compounds are required to underpin the mechanisms of action and ensure its biosafety and efficiency. This comprehensive review provides a scientific basis for future investigations on the use of T. algeriensis and derived compounds in health maintenance and promotion and disease prevention.

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Thymus algeriensis Bioss & Reut: Relationship of phenolic compounds composition with in vitro/in vivo antioxidant and antibacterial activity

Cited by 33 publications

References 69 publications

Molecular Networking Leveraging the Secondary Metabolomes Space of Halophila stipulaceae (Forsk.) Aschers. and Thalassia hemprichii (Ehrenb. ex Solms) Asch. in Tandem with Their Chemosystematics and Antidiabetic Potentials

Molecular Networking Leveraging the Secondary Metabolomes Space of Halophila stipulaceae (Forsk.) Aschers. and Thalassia hemprichii (Ehrenb. ex Solms) Asch. in Tandem with Their Chemosystematics and Antidiabetic Potentials

Chemical Composition, Antioxidant and Enzyme Inhibitory Activities of Onosma bourgaei and Onosma trachytricha and in Silico Molecular Docking Analysis of Dominant Compounds

Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

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