Thymus-Neuroendocrine Network

Fabris, Ν.; Mocchegiani, Eugenio; Muzzioli, Mario; Imberti, Roberto

doi:10.1007/978-1-4684-4547-3_21

Cited by 11 publications

(2 citation statements)

References 42 publications

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“…Alternatively or in addition, GH may act on the thymus by modulating the synthesis and/or release of thymic peptides, as sug gested by experimental observations of low levels of cir culating thymic hormones in congenitally hypopituitary dwarf mice [20], With these premises we have investigated whether human hypopituitarism is associated with a reduced pro duction of thymulin, as measured by the rosette inhibi tion assay, and whether GH injections might influence such an endocrine functioning of the thymus.…”

Section: Introductionmentioning

confidence: 99%

Influence of Growth Hormone on Thymic Endocrine Activity in Humans

Mocchegiani¹,

Paolucci

Balsamo

et al. 1990

Horm Res

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The thymus produces humoral factors that induce the proliferation and differentiation of T cells which are responsible for cell-mediated immunity. Experimental data have suggested that this thymic hormone production is modulated by the neuroendocrine network and, in particular, by growth hormone (GH) and thyroid hormones. To study the role played by GH in thymic endocrine activity in humans, the circulating level of one of the best known thymic peptides, i.e. thymulin (Zn-FTS), has been determined, after a washout period of 2 weeks without GH treatment, in GH-deficient children before and after a single injection of GH. The basal thymulin level is consistently lower in GH-deficient children than in healthy age-matched controls. A single injection of GH induces a significant increment of the thymulin level for at least 48 h. Since thymulin activity may also depend on zinc bioavailability, on thyroid hormone turnover and on the eventual presence of thymulin-inhibitory substances, all these aspects have been checked. No supporting evidence regarding the existence of these kinds of interferences in GH-deficient children has been substantiated. A positive correlation has been found between the serum level of insulin-like growth factor I, but not of GH, and thymulin activity. These data suggest that GH may directly or indirectly modulate the thymic endocrine function in humans. Whether and to what extent such a modulation is relevant to the functioning of the immune system remains to be ascertained.

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Section: Introductionmentioning

confidence: 99%

Influence of Growth Hormone on Thymic Endocrine Activity in Humans

Mocchegiani¹,

Paolucci

Balsamo

et al. 1990

Horm Res

Self Cite

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“…This neurological disease is associated with thymic atrophy; the thymus returns to normal as soon as the neural disturbance disappears [62]. Both thymectomized and nude mice, another mutant strain that shows thymic atrophy, display a profoundly disturbed neuroendocrine balance [63]. There is a report of the extraction from the anterior pituitary of a low molecular weight peptide with thymocyte-stimulating properties [64].…”

Section: Introductionmentioning

confidence: 97%

Psychoneuroimmunology: Interactions between central nervous system and immune system

Solomon

1987

J of Neuroscience Research

204

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Psychoneuroimmunology, a rapidly developing field, has to do with the complex bidirectional interactions between the central nervous system and the immune system. Neuroendocrine influences modulate immune function, and there is feedback from the immune system to the brain. CNS-immune interaction appears to play a role in psychosocial influences on immunologically resisted and mediated diseases. With the growing evidence now at hand, over 30 "postulates" can be proposed for specific implications of CNS-immune interaction.

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Neuroendocrine—Thymus Interactions During Development and Aging

Fabris¹

1994

Bilateral Communication Between the Endocrine and Immune Systems

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Thymus-Neuroendocrine Network

Cited by 11 publications

References 42 publications

Influence of Growth Hormone on Thymic Endocrine Activity in Humans

Influence of Growth Hormone on Thymic Endocrine Activity in Humans

Psychoneuroimmunology: Interactions between central nervous system and immune system

Neuroendocrine—Thymus Interactions During Development and Aging

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