Thymus satureioides Coss. combats oral ulcer via inhibition of inflammation, proteolysis, and apoptosis

Elbatreek, Mahmoud H.; Fathi, Ayman M; Mahdi, Ismail; Abdelfattah, Mohamed A.O.; Mahmoud, Mona F.; Sobeh, Mansour

doi:10.1007/s10787-023-01285-y

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…Network pharmacology is an exciting approach that help reveal the mechanisms of action of herbal extracts ( Mohamed et al, 2022 ; Elbatreek et al, 2023 ). Using this approach facilitated the identification of key potential targets of CGBRE in UC, and the top three included EGFR, LRRK2 and HSP90.…”

Section: Discussionmentioning

confidence: 99%

Casuarina glauca branchlets’ extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies

Mohamed,

El-Shafae,

Fikry

et al. 2023

Front. Pharmacol.

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Ulcerative colitis (UC) is an inflammatory bowel disease that is often resistant to current treatment options, leading to a need for alternative therapies. Herbal products have shown promise in managing various conditions, including UC. However, the potential of Casuarina glauca branchlets ethanolic extract (CGBRE) in treating UC has not been explored. This study aimed to analyze the chemical composition of CGBRE and evaluate its efficacy in UC treatment through in silico and in vivo experiments. LC-ESI-MS/MS was used to identify 86 compounds in CGBRE, with 21 potential bioactive compounds determined through pharmacokinetic analysis. Network pharmacology analysis revealed 171 potential UC targets for the bioactive compounds, including EGFR, LRRK2, and HSP90 as top targets, which were found to bind to key CGBRE compounds through molecular docking. Molecular docking findings suggested that CGBRE may be effective in the prevention or treatment of ulcerative colitis mediated by these proteins, where key CGBRE compounds exhibited good binding affinities through formation of numerous interactions. In vivo studies in rats with acetic acid-induced UC demonstrated that oral administration of 300 mg/kg CGBRE for 6 days reduced UC symptoms and colonic expression of EGFR, LRRK2, and HSP90. These findings supported the therapeutic potential of CGBRE in UC and suggested the need for further preclinical and clinical investigation.

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Section: Discussionmentioning

confidence: 99%

Casuarina glauca branchlets’ extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies

Mohamed,

El-Shafae,

Fikry

et al. 2023

Front. Pharmacol.

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New Perspectives about Relevant Natural Compounds for Current Dentistry Research

Dinu,

Dumitrel,

Buzatu

et al. 2024

Life

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Natural compounds have been used since the earliest civilizations and remain, to this day, a safer alternative for treating various dental problems. These present antimicrobial, anti-inflammatory, antioxidant, analgesic, and antimutagenic effects, making them useful in the prophylactic and curative treatment of various oral diseases such as infections, gingivitis, periodontitis, and even cancer. Due to the high incidence of unpleasant adverse reactions to synthetic compounds, natural products tend to gradually replace conventional treatment, as they can be just as potent and cause fewer, milder adverse effects. Researchers use several methods to measure the effectiveness and safety profile of these compounds, and employing standard techniques also contributes to progress across all medical disciplines.

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Thymus satureioides Coss. combats oral ulcer via inhibition of inflammation, proteolysis, and apoptosis

Cited by 2 publications

References 46 publications

Casuarina glauca branchlets’ extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies

Casuarina glauca branchlets’ extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies

New Perspectives about Relevant Natural Compounds for Current Dentistry Research

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