Thymus vulgaris ameliorates cough in children with asthma exacerbation: a randomized, triple-blind, placebo-controlled clinical trial

Eskandarpour, Elnaz; Ahadi, Adel; Moini Jazani, Arezoo; Nasimi Doost Azgomi, Ramin; Molatefi, Rasol

doi:10.15586/aei.v52i1.964

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The most important component responsible for thyme activity is thymol contained in thyme volatile oil, which, combined with primrose or other natural substances, effectively controls coughing in subjects with upper respiratory tract infections [111,112]. In children with acute asthma, a thyme-based syrup administered every eight hours significantly reduced coughing and improved respiratory function compared to the control group, suggesting its potential use as an adjunct in asthma exacerbation management [113]. In patients with COVID-19, inhalation of thyme oil was effective in relieving symptoms such as shortness of breath, dizziness, secretion, diarrhea, weakness, loss of appetite, coughing, headache, and muscle and joint pain compared to the control group [114].…”

Section: Other Herbal Medicinesmentioning

confidence: 99%

Well-Established and Traditional Use of Vegetal Extracts as an Approach to the “Deep Roots” of Cough

Pecoraro,

Peterle,

Dalla Benetta

et al. 2024

Children

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Cough is a common presenting symptom for patients in a primary care setting and significantly impacts a patient’s quality of life. Cough involves a complex reflex arc beginning with the stimulation of sensory nerves that function as cough receptors that stimulate the cough center in the brain. This “cough center” functions to receive these impulses and produce a cough by activating efferent nervous pathways to the diaphragm and laryngeal, thoracic, and abdominal musculature. Drugs that suppress the neural activity of cough are non-specific as those treatments are not directed toward pathogenic causes such as inflammation and oxidative stress. Moreover, they block a reflex called the watchdog of the lung and have a defense mechanism. Acute respiratory infections of the upper and lower airways most commonly cause acute cough. In contrast, the most common causes of chronic cough are upper airway cough syndrome, asthma, and gastroesophageal reflux disease, all associated with an inflammatory reaction at the level of the cough receptors. The use of natural compounds or herbal drugs such as carob syrup, dry blackcurrant extract, dry extract of caraway fruit, dry extract of ginger rhizome, dry extract of marshmallow root, and dry extract of ivy leaves, to name a few, not only have anti-inflammatory and antioxidant activity, but also act as antimicrobials, bronchial muscle relaxants, and increase gastric motility and empty. For these reasons, these natural substances are widely used to control cough at its deep roots (i.e., contrasting its causes and not inhibiting the arch reflex). With this approach, the lung watchdog is not put to sleep, as with peripheral or central inhibition of the cough reflex, and by contrasting the causes, we may control cough that viruses use at self-advantage to increase transmission.

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Section: Other Herbal Medicinesmentioning

confidence: 99%

Well-Established and Traditional Use of Vegetal Extracts as an Approach to the “Deep Roots” of Cough

Pecoraro,

Peterle,

Dalla Benetta

et al. 2024

Children

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Phytochemical Profiling and Therapeutic Potential of Thyme (Thymus spp.): A Medicinal Herb

Waheed,

Hussain,

Saeed

et al. 2024

Food Science & Nutrition

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Thymol is a phenol monoterpene that is naturally derived from cymene and is an isomer of carvacrol. It constitutes a significant portion (10%–64%) of the essential oils found in thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant renowned for its therapeutic properties. Wild thyme is native to the Mediterranean region and has been used in cooking and medicine for a long time. In contemporary contexts, both thymol and thyme offer diverse functional applications in the pharmaceutical, food, and cosmetic industries. Thymol has attracted scientific interest for its potential therapeutic applications in pharmaceuticals and nutraceuticals. Studies have explored its efficacy in treating respiratory, nervous, and cardiovascular disorders, highlighting its promising role in diverse therapeutic interventions. Additionally, this compound demonstrates antimicrobial, antioxidant, anticarcinogenic, anti‐inflammatory, and antispasmodic properties. It also shows potential as a growth enhancer and has immunomodulatory properties as well. Other discussed aspects include thymol toxicity, bioavailability, metabolism, and distribution in animals and humans. This review summarizes the most significant data regarding the beneficial effects of thyme bioactive compounds and their applications as a food preservative while taking into account the thyme plant extract and its essential oil.

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Neuromodulators in Acute and Chronic Cough in Children: An Update from the Literature

Foti Randazzese,

Toscano,

Gambadauro

et al. 2024

IJMS

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Cough is one of the most common reasons leading to pediatric consultations, negatively impacting the quality of life of patients and caregivers. It is defined as a sudden and forceful expulsion of air from the lungs through the mouth, typically triggered by irritation or the stimulation of sensory nerves in the respiratory tract. This reflex is controlled by a neural pathway that includes sensory receptors, afferent nerves, the brainstem’s cough center, efferent nerves, and the muscles involved in coughing. Based on its duration, cough in children may be classified as acute, lasting less than four weeks, and chronic, persisting for more than four weeks. Neuromodulators have shown promise in reducing the frequency and severity of cough by modulating the neural pathways involved in the cough reflex, although they require careful monitoring and patient selection to optimize the outcomes. This review aims to examine the rationale for using neuromodulators in the management of cough in children.

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Thymus vulgaris ameliorates cough in children with asthma exacerbation: a randomized, triple-blind, placebo-controlled clinical trial

Cited by 3 publications

References 21 publications

Well-Established and Traditional Use of Vegetal Extracts as an Approach to the “Deep Roots” of Cough

Well-Established and Traditional Use of Vegetal Extracts as an Approach to the “Deep Roots” of Cough

Phytochemical Profiling and Therapeutic Potential of Thyme (Thymus spp.): A Medicinal Herb

Neuromodulators in Acute and Chronic Cough in Children: An Update from the Literature

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