Thymus vulgaris extract modulates dexamethasone induced liver injury and restores the hepatic antioxidant redox system

Abou-Seif, Howida Sayed; Hozayen, Walaa G.; Hashem, Khalid S.

doi:10.1186/s43088-019-0021-0

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…The rats pretreated with glibenclamide and those treated with plant extract had significantly lower ASAT activity. These findings are comparable to those of Abou-Seif et al [24], which demonstrated the ameliorative impact of Thymus vulgaris extract on dexamethasone-induced liver injury and dysfunction, and would indicate a hepatomodulatory action of S. magnificum aqueous extract.…”

Section: Discussionsupporting

confidence: 89%

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

Kepta¹,

Medou²,

Nyunaï³

et al. 2021

GSC Adv. Res. Rev.

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This study aimed to evaluate the effect of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin-resistant male rats. Firstly, a phytochemical screening of the aqueous extract was carried out. Thereafter, using acute and subacute studies (11 days), the effect of the extract (200 mg/kg and 400 mg/kg) was evaluated on dexamethasone-induced hyperglycemic rats. Glycemia was measured before and after treatment in both studies. Histological examinations for isolated liver, kidneys, and pancreas were performed, body and the weight of some internal organs was determined. The biochemical assay in the blood samples was performed only for the subacute study. Phytochemical analysis revealed that the extract contains phenolic compounds, flavonoids, anthocyanins, saponins, gallic tannins, coumarins, and anthraquinones. In both studies, Schumanniophyton magnificum stem bark aqueous extract reduced the glucose blood Area under the Curve produced by dexamethasone injection. The extract, as well as glibenclamide significantly lowered the dexamethasone-induced increase in transaminases activities and uric acid concentration. Superoxide dismutase activity increased in all extract and glibenclamide groups compared to the dexamethasone group. The extract effect on the glutathione concentration was dose-dependent (p < 0.05 and p < 0.001 respectively). The histology of organs from rats treated with dexamethasone revealed hepatic cytolysis, leukocyte infiltration, and islet hypotrophy. The extract nd glibenclamide-treated groups had fewer or no anomalies observed with dexamethasone administration. Aqueous extract of S. magnificum stem bark protects against dexamethasone-induced pancreatic and hepatorenal abnormalities, probably due to the antioxidant properties of the chemical groups present in this extract.

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Section: Discussionsupporting

confidence: 89%

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

Kepta¹,

Medou²,

Nyunaï³

et al. 2021

GSC Adv. Res. Rev.

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“…Hasona and Morsi [16] and Hasona et al [14] have reported elevations in liver function markers in dexamethasone administered rats. Abou-Seif [78] have also demonstrated that dexamethasone induced liver injury was reflected by raised SGOT, SGPT and LDH levels along with disturbed histoarchitecture. LycT supplementation to dexamethasone treated mice decreased the enhanced levels of these markers which is suggestive of mitigation of hepatic damage and preserved membrane integrity.…”

Section: Discussionmentioning

confidence: 94%

Protective Potential of Lycopene Enriched Tomato Extract against Dexamethasone Induced Hepatic and Renal Damage in Mice

Koul¹,

Kaur²,

Chugh³

2021

AJRB

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Aim: The present study was carried out to determine the protective potential of Lycopene enriched tomato extract (LycT) against hepatic and renal damage caused in mice by dexamethasone administration. Study Design: Male LACA mice were randomly divided into four treatment groups (n=6-7 animals per group) depending upon the treatment they received. Group I (control) animals served as control and were orally administered with olive oil (vehicle) thrice a week for five weeks. Group II (DEX) animals were intraperitoneallly (i.p.) administered with dexamethasone at a dose of 5 mg/kg b.w. on alternate days for three weeks. Group III (LycT) animals were orally (p.o.) administered with LycT at a dose of 5 mg/kg b.w. on alternate days for five weeks. Group IV (LycT+DEX) animals were co-administered with LycT (p.o.) and dexamethasone (i.p.) according to the above mentioned dose regimen Results: Dexamethasone caused hepatic and renal damage as evident from disturbed histoarchitecture, deranged levels of organ function markers (alkaline phosphatase, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, total and direct bilirubin, urea, creatinine) and enhanced level of cell damage (lactate dehydrogenase) and oxidative stress (lipid peroxidation) markers. Increased blood glucose level, decreased hepatic glycogen level along with inhibited activities of enzymes involved in glycolysis (hexokinase, phosphoglucoisomerase) indicated altered glucose metabolism in DEX group. The mitigation in histoarchitectural alterations, cell damage and oxidative stress markers, improved levels of organ function markers, blood glucose level along with ramped up antioxidant defense system indicated the protective potential of LycT against dexamethasone induced ill effects. Conclusions: These results point towards beneficial effects of LycT against dexamethasone induced damage to hepatic and renal tissues in mice.

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“…When comparing the dexamethasone and garlic extract-treated group 3 with the dexamethasonetreated group 2, there was a significant improvement in the three parameters [P < 0.0001]. Similarly, when comparing the dexamethasone and garlic extract treated group [3] with the control group [1], FBS, insulin levels and HOMA-IR were significantly higher [P < 0.0001 for FBS and HOMA-IR and P < 0.005 for insulin]; meaning that treatment with garlic extract causes improvement in these parameters but is still significantly higher than the control group [Figure 3].…”

Section: Resultsmentioning

confidence: 98%

“…Dexamethasone is an effective immunesuppressive and anti-inflammatory agent however, its use may have several side effects, for example, hepatic injury, skeletal muscle atrophy, and insulin resistance. Dexamethasone increases the production of free radicals which in turn increases oxidative stress-mediated tissue damage [3] .…”

Section: Introductionmentioning

confidence: 99%

Study of the protective effect of garlic water extract on dexamethasone-induced hepatotoxicity and insulin resistance in adult male albino rats

Alkot

Naeem²,

Sayed³

et al. 2022

International Journal of Medical Arts

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Article informationBackground: The liver has an essential role in the metabolism and detoxification of various metabolites and drugs so it is liable to injury. Long-term use of dexamethasone may cause hepatic injury and insulin resistance. Garlic contains a variety of effective compounds that exhibit antioxidant, hypocholesterolemic, hypoglycemic, antithrombotic, antibiotic, anticancer, as well as hypotensive activities.Objective: To study the effect of garlic water extract on hepatic toxicity and insulin resistance induced by dexamethasone in adult male albino rats. Materials and Methods:Twenty-four adult male albino rats of a local strain were divided into three equal groups, group 1 [control group], group 2 [dexamethasone-treated group], and group 3 [dexamethasone and garlictreated group]. After two weeks from the onset of the experiment serum was isolated from blood samples for assessment of Alanine Transaminase [ALT], Aspartate Transaminase [AST], serum albumin, Alkaline Phosphatase [ALP], total bilirubin, fasting blood glucose [FBG], and Fasting insulin level. Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] was then calculated. Samples of the liver were taken for histopathological studies.Results: There was a significant elevation in ALT, AST, ALP, and total bilirubin and a significant reduction in serum albumin in the dexamethasone-treated group when compared with the control group. ALT, AST, ALP, and total bilirubin significantly improved in the dexamethasone and garlic extracttreated group. Also, there was a significant elevation in FBS, insulin level, and HOMA-IR in the dexamethasone-treated group when compared with the control group. These parameters were significantly decreased in the dexamethasone and garlic extract-treated group when compared with the dexamethasone-only treated group. Conclusion:Garlic water extract showed a potential protective effect against dexamethasone-induced liver injury and insulin resistance.

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Thymus vulgaris extract modulates dexamethasone induced liver injury and restores the hepatic antioxidant redox system

Cited by 11 publications

References 37 publications

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

Protective Potential of Lycopene Enriched Tomato Extract against Dexamethasone Induced Hepatic and Renal Damage in Mice

Study of the protective effect of garlic water extract on dexamethasone-induced hepatotoxicity and insulin resistance in adult male albino rats

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