Thyrocalcitonin: Effect on Idiopathic Hypercalcemia

Abstract

Identical twins having idiopathic hypercalcemia were treated with repeated doses of thyrocalcitonin extracted from porcine thyroid glands. The treatment produced a marked change in the amount of calcitum and phosphate in the plasma and in the excretion of urinary calcium.

Effet hypocalcémiant de la thyrocalcitonine chez l'enfant normal et l'enfant hypothyroïdien

“…On peut remarquer la similitude qui existe entre 1'effet hypocalcemiant de la thyrocalcitonine chez les enfants hypothyroidiens etudies ici et chez deux enfants atteints d'hypercalcemie par hypersensibilite a la vitamine D, ou syndrome de LIGHTWOOD [7,18]. Dans les deux cas, l'amplitude et la duree de la reponse hypocalcemique sont plus importantes que chez les enfants normaux.…”

Effect of Calcitonin and Hexestrol on Urinary Excretion of Hydroxyproline in a Patient with Prostatic Cancer and Bone Metastases

“…Calcitonin also has been shown to be therapeutically effective in treating Paget's disease (Bijvoet et al, 1968;Haddad et al, 1970). Several workers have shown a lowering of serum calcium upon administration of calcitonin to patients with hypercalcemia which was idiopathic (Milhaud and Job, 1966) or secondary to malignancy (Bijvoet et al, 1968;Pak et al, 1968). Pak et al, (1968) reported a case with parathyroid carcinoma and hyperparathyroidism who responded to calcitonin therapy with a fall in serum and urinary calcium, with a change in calcium balance from negative toward positive.…”

Biology and Medicine Semiannual Report, Fall 1969.

“…The possibility that changes in marrow function play an important part of the pathogenesis of age-related osteoporosis has been proposed (21). Agents which affect other bone diseases, e. g., calcitonin (22,23) and mithramycin (24,25) (11/11) …”