1978
DOI: 10.1073/pnas.75.1.45
|View full text |Cite
|
Sign up to set email alerts
|

Thyroid and glucocorticoid hormones synergistically control growth hormone mRNA in cultured GH1 cells.

Abstract: We have previously demonstrated that thyroid hormone controls growth hormone synthesis in GH1 cells and that the induction of the growth hormone response by glucocorticoid appears to be highly dependent on thyroid hormone action. Thyroid hormone induces growth hormone synthesis approximately 5-to 20-fold and cortisol increases this response 2-to 6-fold further. Long-term kinetics of the growth hormone response show that, without added thyroid hormone, cortisol can induce a small-growth hormone response after 4… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

3
37
0
1

Year Published

1979
1979
1999
1999

Publication Types

Select...
6
2

Relationship

1
7

Authors

Journals

citations
Cited by 160 publications
(41 citation statements)
references
References 26 publications
3
37
0
1
Order By: Relevance
“…If glucocorticoids and thyroid hormones do act through different biochemical mechanisms to stimulate phospholipid synthesis, then it is possible that administration of both hormones together would produce an additive effect. This proposal is supported by the reported interaction of steroids and T3 in other systems (46)(47)(48)(49).…”
Section: Discussionsupporting
confidence: 73%
“…If glucocorticoids and thyroid hormones do act through different biochemical mechanisms to stimulate phospholipid synthesis, then it is possible that administration of both hormones together would produce an additive effect. This proposal is supported by the reported interaction of steroids and T3 in other systems (46)(47)(48)(49).…”
Section: Discussionsupporting
confidence: 73%
“…This interaction appears to occur predominately at a pretranslational level. Similarly, T3 and cortisol interact synergistically in the induction of the specific mRNA for growth hormone in GH, cells, a cell line derived from a rat pituitary tumor (33).…”
Section: Resultsmentioning
confidence: 99%
“…In this system, L-triiodothyronine (L-T3)1 stimulates a 3-to 10-fold increase in the rate of growth hormone synthesis (2,5,7) which is paralleled by changes in total cytoplasmic growth hormone imessenger RNA (mRNA) levels (8). The physiological relevence of this effect in GH1 cells is underscored by the observation that thyroid hormone plays an important role in controlling the production of growth hormone in the rat pituitary in vivo (9)(10)(11)(12), although thyroid growth hormone has been reported to have an equivocal effect on growth hormone production in dispersed anterior pituitary cells in vitro (13).…”
Section: Introductionmentioning
confidence: 99%
“…We have previously documented that GHl cells, a growth hormone-producing rat pituitary cell line, is a valid culture system which can be used to define the molecular action of physiological concentrations of thyroid hormone in mammalian cells (1)(2)(3)(4)(5)(6)(7)(8). In this system, L-triiodothyronine (L-T3)1 stimulates a 3-to 10-fold increase in the rate of growth hormone synthesis (2,5,7) which is paralleled by changes in total cytoplasmic growth hormone imessenger RNA (mRNA) levels (8).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation