Thyroid Cancer: 1999 Update and Evaluation of Solitary Thyroid Nodules

Tyler, Douglas S.; Shaha, Ashok R.; Udelsman, Robert; Sherman, Steven I.; Thompson, Norman W.; Moley, Jeffrey F.; Evans, Douglas B.

doi:10.1007/s10434-000-0376-3

Cited by 37 publications

(8 citation statements)

References 113 publications

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“…Bilateral metastatic neck involvement was demonstrated in 50% of cases. It has been demonstrated that metastatic disease, locoregional and distant, seems to be most important prognostic factor for the good response to therapy [25]. Data from present study clearly demonstrate the significance of detailed preoperative neck examination and careful intraoperative exploration, with special emphasis on lateral neck regions.…”

Section: Discussionsupporting

confidence: 66%

Surgical and Pathological Characteristics of Papillary Thyroid Cancer in Children and Adolescents

Džepina

2012

International Journal of Pediatrics

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Background. Thyroid carcinoma is a relatively rare pediatric pathology, comprising around 3% of all childhood tumors. We investigated parameters of tumor aggressiveness, multicentricity, and locoregional metastatic spread patterns in patients up to 18 years of age and made comparison with the older group. All patients were operated upon with total thyroidectomy, with or without lymph-node neck dissection. Results. Patients with papillary carcinoma present with more advanced stage, larger primary tumor, and more commonly present with palpable thyroid and/or neck node. Overall, papillary cancer demonstrated pathological aggressiveness as defined by our criteria in 60%, multicentricity in 40%, and locoregional metastatic foci in 77% of cases. Multicentric tumor foci in both thyroid lobes and tumor aggressiveness were identified as a risk factor for metastatic development. Conclusion. By observing clinicopathological parameters, we demonstrated that papillary thyroid cancer behaves more aggressively in the younger group. We recommend total thyroidectomy with careful intraoperative exploration of thyroid bed and lateral neck in search for possible metastatic spread. In case of positive findings, it is obligatory to perform a standard neck dissection, keeping in mind that neck lymphonodes are primary site of locoregional recurrence. With meticulous attention to technical aspects of operation, perioperative morbidity should be minimal.

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Section: Discussionsupporting

confidence: 66%

Surgical and Pathological Characteristics of Papillary Thyroid Cancer in Children and Adolescents

Džepina

2012

International Journal of Pediatrics

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“…The estimated prevalence in the global population is from 4% to 7% (8). Further, postmortem examination and high-resolution ultrasound studies suggest that up to 50% of the general population may have thyroid nodule(s) (8)(9)(10). In absolute terms, the incidence of thyroid cancer runs up to about 18,000 new cases per year in the United States (11).…”

Section: Introductionmentioning

confidence: 98%

Serum Galectin-1 and Galectin-3 Levels in Benign and Malignant Nodular Thyroid Disease

Saussez

Glinoer

Chantrain

et al. 2008

Thyroid

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“…Only 5–15% of the thyroid nodules in clinics are malignant 5 6 , which include follicular thyroid carcinomas (FTC), papillary thyroid carcinomas (PTC), medullary thyroid carcinomas (MTC), anaplastic thyroid carcinomas (ATC), thyroid lymphomas and metastatic carcinomas. PTC and FTC are differentiated thyroid carcinomas, which are the most common forms of thyroid cancer 7 .…”

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confidence: 99%

Integrative metabonomics as potential method for diagnosis of thyroid malignancy

Tian

Nie

et al. 2015

Sci Rep

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Thyroid nodules can be classified into benign and malignant tumors. However, distinguishing between these two types of tumors can be challenging in clinics. Since malignant nodules require surgical intervention whereas asymptomatic benign tumors do not, there is an urgent need for new techniques that enable accurate diagnosis of malignant thyroid nodules. Here, we used 1H NMR spectroscopy coupled with pattern recognition techniques to analyze the metabonomes of thyroid tissues and their extracts from thyroid lesion patients (n = 53) and their adjacent healthy thyroid tissues (n = 46). We also measured fatty acid compositions using GC−FID/MS techniques as complementary information. We demonstrate that thyroid lesion tissues can be clearly distinguishable from healthy tissues, and malignant tumors can also be distinguished from the benign tumors based on the metabolic profiles, both with high sensitivity and specificity. In addition, we show that thyroid lesions are accompanied with disturbances of multiple metabolic pathways, including alterations in energy metabolism (glycolysis, lipid and TCA cycle), promotions in protein turnover, nucleotide biosynthesis as well as phosphatidylcholine biosynthesis. These findings provide essential information on the metabolic features of thyroid lesions and demonstrate that metabonomics technology can be potentially useful in the rapid and accurate preoperative diagnosis of malignant thyroid nodules.

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Thyroid Cancer: 1999 Update and Evaluation of Solitary Thyroid Nodules

Cited by 37 publications

References 113 publications

Surgical and Pathological Characteristics of Papillary Thyroid Cancer in Children and Adolescents

Surgical and Pathological Characteristics of Papillary Thyroid Cancer in Children and Adolescents

Serum Galectin-1 and Galectin-3 Levels in Benign and Malignant Nodular Thyroid Disease

Integrative metabonomics as potential method for diagnosis of thyroid malignancy

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