Thyroid Cancer and Nonsteroidal Anti-Inflammatory Drug Use: A Pooled Analysis of Patients Older Than 40 Years of Age

Hwangbo

et al. 2020

Thyroid

Background: While aspirin use is known to be associated with reduced incidence of various cancer types, it is unclear whether this benefit extends to thyroid cancer. We aimed to evaluate the association between aspirin use and thyroid cancer development. Methods: This nested case-control study used nationwide data from the Korean National Health Insurance Service-National Sample Cohort 2002-2015. In total, 4547 individuals with newly developed thyroid cancer were matched with 13,641 controls based on age, sex, and follow-up period. Odds ratios (ORs) and 95% confidence intervals (CIs) for thyroid cancer development according to aspirin use were analyzed using a multivariable conditional logistic regression model. Results: The number of days for which patients with thyroid cancer used aspirin (the proportions of no use, <30 days/year, 30-90 days/year, and ‡90 days/year were 93.03%, 6.51%, 0.31%, and 0.15%, respectively) was comparable with that of the controls ( p = 0.371, chi-squared test). The risk of thyroid cancer development was not associated with the duration of aspirin use (ORs [CI] for aspirin use <30 days/year, 30-90 days/year, and ‡90 days/year were 1.11 [0.96-1.28], 1.01 [0.54-1.88], and 1.23 [0.50-3.06], respectively, compared with no use) after adjusting for body mass index, smoking status, hypertension, Charlson comorbidity index, and number of outpatient visits per year. In addition, subgroup analyses stratified by age, sex, and follow-up duration did not reveal any significant association between aspirin use and thyroid cancer. Conclusions: Our findings suggest that even extended aspirin use may not impact the prevention or onset of thyroid cancer.

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aspirin Use Is Not Associated with Lower Thyroid Cancer Risk: A Nationwide Nested Case–Control Study

Hwangbo

et al. 2020

Thyroid

“…В іншій роботі зв'язок РЩЗ з ІМТ спостерігався в різних діапазонах, але найвищі показники були визначені для ІМТ ≥31,7 та зросту ≥170 см для жінок і ≥180 см для чоловіків [7]. Ще низка досліджень продемонструвала схожі результати щодо надмірної маси тіла та ожиріння як потенційного фактору ризику ЗНЩЗ [46,59]. Мета-аналіз Ma J. et al (2015), до якого було залучено 32 дослідження, також підтверджує розглянуті припущення щодо ожиріння (RR=1,33, 95% ДІ: 1,24-1,42), за виключенням медулярної карциноми [60].…”

Section: в п о м о щ ь п р а к т и ч е с к о м у в р а ч уunclassified

“…et al (2017) і Patel D. еt al. (2015) визначили, що ризик розвитку РЩЗ у жінок вище, ніж у чоловіків у середньому у 3-4 рази[5,46]. Превалювання ЗНЩЗ серед жінок дітородного віку вказує на роль естрогенів, прогестеронів та їхніх специфічних рецепторів (ERβ, ERα) у ракових клітинах ЩЗ, проте що саме відповідає за їхню експресію не визначено[47, 48].Також було проведено багато досліджень з приводу зв'язку ЗНЩЗ та , як вік початку менархе і менопаузи, тривалість менструації, кількість вагітностей і пологів та інші параметри[49,50], однак наведені докази непереконливі та суперечливі.…”

unclassified

Modern view on the risk factors for malignant tumors of the thyroid gland: a systematic review

Ткаченко

Рімар

2018

FMEP

The morbidity of thyroid carcinoma (TC) tends to annual growth. The results of the multifactorial studies of the development of thyroid carcinogenesis testify the insufficient knowledge about the influence and significance of certain TC factors, which requires systematization in order to improve the oncoepidemic situation in the country.The objective: of this study was to conduct an analytical systematic review of literature to resume risk factors of TC in the last 10 years.Materials and methods. The generalization of literary sources, founded by key words in Google Scholar, PubMed and eLIBRARY.ru for 2007 to 2017 was carried out. We analyzed the value of the odds ratio (OR), the relative risk (RR), the hazard ratio (HR), standardized incidence ratio (SIR) and an excess relative risk (ERR) with respective confidence intervals (95% CI), as well as the reliability value (p).Results. The most significant risk factors for TC are: ionizing radiation (increases the incidence in 1,3–5 times); previous thyroid disease (associated with TC in 30–94% cases, most goiter, adenoma and AIT – in 29,7%, OR=2,12; RR=1,4), heredity (presence of TC in I degree relatives increases the chance of occurrence in > 4-times), systemic autoimmune disease (SLE increases the risk 1,8 times), diabetes (TC risk increases on 18–20%), menstrual and reproductive factors (increased risk in 1,2–2,4 times), anthropometric factors (high height – increases the risk in 1,2–1,6 times, BMI ≥30 kg/m2 – in 1,35–1,7 times, and the waist >90 cm in women – in 1,3 times); benign breast disease (TC risk is higher on 38–56%), breast cancer (TC risk increases in 1,4–2,3 times), deficiency of vitamin D (TC risk increases 2–6 times), the persistence of virus, insufficient iodine intake, lifestyle – the use of certain products and physical activity, anthropogenic and occupational factors.Conclusion. The primary care physician should take into account the current understanding of the risk ТС factors in patients, especially in high-risk groups.

“…It is also necessary to study this problem from the perspective of factors such as environmental factors and molecular mechanisms [3,4] .The real cause of the increase in the incidence of thyroid cancer has not yet been determined; however, environmental factors or lifestyle may contribute to this increase. Several epidemiological studies have confirmed that obesity is positively correlated with the increased risk of thyroid cancer [5][6][7][8].However, the correlation between obesity and the invasive clinicopathological features of thyroid cancer remains controversial. [9][10][11][12] In this study, the Chinese body mass index (BMI) classification criteria were used to explore whether the clinicopathological characteristics of PTC are different among patients with different BMIs.…”

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Correlation between obesity and clinicopathological characteristics in patients with papillary thyroid cancer: a study of 1579 cases: a retrospective study (v0.1)"

2020

To explore the relationship between body mass index (BMI) and clinicopathological characteristics in patients with papillary thyroid carcinoma (PTC). Methods: The clinical data of 1579 patients with PTC, admitted to our hospital from May 2016 to March 2017, were retrospectively analyzed. According to the different BMI of patients, it can be divided into underweight recombination(BMI<18.5 kg/m), normal body recombination(24.0 ≥ BMI < 28.0 kg/m2), overweight recombination(24.0 ≥ BMI < 28.0 kg/m2) and obesity group(BMI ≥28.0 kg/m2). The clinicopathological characteristics of PTC in patients with different BMIs group were compared. Results: In our study, the risk for extrathyroidal extension (ETE), advanced T stage (T III/IV), and advanced tumor-node-metastasis stage (TNM III/IV) in the overweight group were higher, with OR(odds ratio)= 1.99(1.41-2.81),OR=2.01(1.43-2.84), OR=2.94(1.42-6.07), respectively, relative to the normal weight group. The risk for ETE and T III/IV stage in the obese group were higher, with OR=1.82(1.23-2.71) and OR=1.82(1.23-2.70), respectively, relative to the normal weight group. Conclusion: BMI is associated with the invasiveness of PTC. There is a higher risk for ETE and TNM III/IV stage among patients with PTC in the overweight group and for ETE among patients with PTC in the obese group.