Thyroid Cancer Metabolism: A Review

Gill, Kurren S.; Tassone, Patrick; Hamilton, James; Hjelm, Nikolaus; Luginbuhl, Adam; Cognetti, David M.; Tuluc, Madalina; Martinez‐Outschoorn, Ubaldo; Johnson, Jennifer M.; Curry, Joseph

doi:10.4172/2167-7948.1000200

Cited by 11 publications

(10 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results might be interpreted as representative of the shift from aerobic toward anaerobic glycolysis. The decrease of LDH activity in anaplastic carcinoma compared to that in differentiated carcinoma (Gill et al, 2016) and has been confirmed by Valvona et al (2016) who stated that the activity enzymes of the citric acid cycle were inversely proportionate to the mitotic activity. Furthermore, Slavov et al (2014) studied the relationship between the metabolisms of cell division and tumor growth.…”

Section: Discussionmentioning

confidence: 71%

Vitamin C Increases the Level of Lactate Dehydrogenase in Rats ‘Oral Squamous Cell Carcinoma

Hadad¹,

Bioinformatics²

2018

JEBAS

View full text Add to dashboard Cite

Since the discovery of vitamin C many studies have illustrated its characteristic effect as a tumor prevention agent. Conversely: the extracellular presence of lactate dehydrogenase (LDH) is associated with cell necrosis and tissue breakdown and is therefore considered as a tumor marker. In present study effects of vitamin C on the levels of oral LDH was estimated during the development of squamous oral carcinoma. Histological findings of study revealed changes in the oral tissue of the animals treated with dimethyl benzanthracene (DMBA) alone or DMBA associated with vitamin C such as moderate dysplasia associated with basal cell hyperplasia. Notably: differentiated oral squamous cell carcinoma was observed in the rats belonging to group injected with DMBA after 6 weeks. Otherwise: anaplastic oral carcinoma was observed after 5 weeks in group treated with DMBA and vitamin C. High levels of LDH were detected throughout the induction of the squamous cell carcinoma phases in comparison to the anaplastic phase. These findings demonstrate that the injection of DMBA in association with vitamin C accelerates the induction of anaplastic carcinoma and that these changes are associated with increased LDH levels in the differentiated squamous carcinoma compared with the undifferentiated carcinomas.

show abstract

Section: Discussionmentioning

confidence: 71%

Vitamin C Increases the Level of Lactate Dehydrogenase in Rats ‘Oral Squamous Cell Carcinoma

Hadad¹,

Bioinformatics²

2018

JEBAS

View full text Add to dashboard Cite

show abstract

“… 16 , 88 It has a low affinity for lactate, and its primary function is to transport intracellular lactate out of the cell. 89 Studies have reported that MCT4 expression is mainly regulated by cell metabolism and the hypoxic environment. 90 In addition to these two transporters, MCT8, a member of the MCT family, is related to TH transport and is also distributed in the thyroid gland.…”

Section: Monocarboxylate Transporters (Mcts) and Metabolism In Tcmentioning

confidence: 99%

“…Studies have confirmed that the expression levels of MCT1 and MCT4 are increased to varying degrees in different types of TC. 89 , 99 , 100 Pioneering researchers conducted an immunohistochemical analysis of orthotopic xenograft tumors and clinicopathological specimens and found that MCT1 was highly expressed relative to MCT4 in anaplastic TC (ATC). 87 Nahm et al conducted a similar experiment with the clinicopathological specimens of 566 patients with TC and immunohistochemically analyzed the expression of proteins related to tumor glycolysis.…”

Section: Monocarboxylate Transporters (Mcts) and Metabolism In Tcmentioning

confidence: 99%

<p>Physiological and Pathophysiological Roles of Ion Transporter-Mediated Metabolism in the Thyroid Gland and in Thyroid Cancer</p>

Cheng

et al. 2020

OTT

View full text Add to dashboard Cite

Thyroid cancer is the most common type of endocrine tumor and has shown an increasing annual incidence, especially among women. Patients with thyroid cancer have a good prognosis, with a high five-year survival rate; however, the recurrence rate and disease status of thyroid cancer remain a burden for patients, which compels us to further elucidate the pathogenesis of this disease. Recently, ion transporters have gradually become a hot topic in the field of thyroid gland biology and cancer research. Additionally, alterations in the metabolic state of tumor cells and protein molecules have gradually become the focus of scientific research. This review focuses on the progress in understanding the physiological and pathophysiological roles of ion transporter-mediated metabolism in both the thyroid gland and thyroid cancer. We also hope to shed light on new targets for the treatment and prognosis of thyroid cancer.

show abstract

“…The incidence of thyroid cancer, one of the most common endocrine tumors, is increasing worldwide. Malignant thyroid cancer can be classified into four main types comprising papillary, follicular, medullary, and anaplastic thyroid cancer (ATC) [ 1 , 2 ]. ATC is one of the most lethal malignancies owing to poor differentiation and invasion into the surrounding tissues, such as the trachea [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Effects of Ursi Fel Extract and Its Active Compound, Ursodeoxycholic Acid, in FRO Anaplastic Thyroid Cancer Cells

Jung

Hwang

2021

Molecules

View full text Add to dashboard Cite

Anaplastic thyroid cancer (ATC) is one of the most fatal human malignancies. Ursi Fel (UF) is the bile of a brown bear that has been traditionally used for heat clearance and toxin relief in Korean and Chinese medicines. In this study, we determined the anticancer effects of a UF extract and its active compound, ursodeoxycholic acid (UDCA), in FRO human ATC cells. FRO cells were treated with UF extract and UDCA at different concentrations for various durations. Cell viability was measured using an MTT assay. Cell apoptosis was investigated by flow cytometric analysis following Annexin V and propidium iodide (PI) staining, and Hoechst staining was used to observe nuclear fragmentation. The expression of pro-apoptotic (Bax, caspase-3, cytochrome c, and PARP), anti-apoptotic (Bcl-2), and angiogenetic (TGF-β, VEGF, N-cadherin, and sirtuin-1) proteins and the phosphorylation of Akt and mechanistic target of rapamycin (mTOR) were determined by western blot analysis. Treatment with UF extract at 10, 25, and 50 μg/mL and UDCA at 25, 50, and 100 μM/mL significantly inhibited the growth of FRO cells in a dose-dependent manner. Flow cytometry and Hoechst staining revealed an increase in the apoptosis of FRO cells mediated by UF extract and UDCA in a dose-dependent manner. UF extract (25 and 50 μg) and UDCA (50 and 100 μM) significantly increased the expression of Bax, caspase-3, cytochrome c, and PARP and inhibited the expression of Bcl-2, TGF-β, VEGF, N-cadherin, and sirtuin-1 in FRO cells. Furthermore, UF extract and UDCA treatment stimulated Akt phosphorylation and inhibited mTOR phosphorylation in these cells. These results indicate that UF extract and UDCA exert anticancer properties in FRO cells by inducing apoptosis and inhibiting angiogenesis via regulating the Akt/mTOR signaling pathway.

show abstract

Thyroid Cancer Metabolism: A Review

Cited by 11 publications

References 74 publications

Vitamin C Increases the Level of Lactate Dehydrogenase in Rats ‘Oral Squamous Cell Carcinoma

Vitamin C Increases the Level of Lactate Dehydrogenase in Rats ‘Oral Squamous Cell Carcinoma

<p>Physiological and Pathophysiological Roles of Ion Transporter-Mediated Metabolism in the Thyroid Gland and in Thyroid Cancer</p>

Anticancer Effects of Ursi Fel Extract and Its Active Compound, Ursodeoxycholic Acid, in FRO Anaplastic Thyroid Cancer Cells

Contact Info

Product

Resources

About