Thyroid Crisis

Greene, Earle I.; Greene, Jerry M.

doi:10.1097/00000658-193204000-00008

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on these findings from two large prospective trials performed in Japan, it is recommended that large doses of inorganic iodide be administered concurrently with ATDs to patients with GD complicated with TS. Indeed, before ATDs were developed, administration of inorganic iodide was the most reliable treatment for TS ( 2 ).…”

Section: Management and Treatment Of Tsmentioning

confidence: 99%

“…T he term “thyroid storm” (TS) or crisis appeared in the literature in the late 1920s. For example, in 1928, Lahey gave this early description: “The following remarks concerning thyroid crises and their management are prompted by the fact that so many patients are constantly being brought to the hospital in advanced stages of thyroid crisis and because so many of these inoperable patients die in spite of employment of every measure with which we are acquainted” ( 1 , 2 ). At that time, the principal measures to manage this condition were iodine, fluids, glucose, and morphine.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid Storm: A Japanese Perspective

Akamizu

2018

Thyroid

105

View full text Add to dashboard Cite

Background: Thyroid storm (TS) is life threatening. In the mid-2000s, its incidence was poorly defined, peer-reviewed diagnostic criteria were not available, and management and treatment did not seem to be verified based upon evidence and latest advances in medicine.Methods: First, diagnostic criteria were developed based on 99 patients in the literature and seven patients in this study. Then, initial and follow-up surveys were conducted from 2004 through 2008, targeting all hospitals in Japan to obtain and verify information on patients who met diagnostic criteria for TS. Based on these data, the diagnostic criteria were revised, and management and treatment guidelines were created.Results: The incidence of TS in hospitalized patients in Japan was estimated to be 0.20 per 100,000 per year and 0.22% of all thyrotoxic patients. The mortality rate was 10.7%. Multiple organ failure was the most common cause of death, followed by congestive heart failure, respiratory failure, and arrhythmia. In the final diagnostic criteria for TS, the definition of jaundice as serum bilirubin concentration >3 mg/dL was added. Based upon nationwide surveys and the latest information, guidelines for the management and treatment for TS were extensively revised and algorithms were developed.Conclusions: TS remains a life-threatening disorder, with >10% mortality in Japan. New peer-reviewed diagnostic criteria for TS are presented and its clinical features, prognosis, and incidence are clarified based on nationwide surveys. Furthermore, this information helped to establish detailed guidelines for the management and treatment of TS. A prospective prognostic study to validate the guidelines is eagerly anticipated.

show abstract

Section: Management and Treatment Of Tsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%