Thyroid disorders and bone mineral metabolism

Dhanwal, Dinesh

doi:10.4103/2230-8210.83339

Cited by 65 publications

(52 citation statements)

References 31 publications

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“…We also measured some of the parameters of bone profile like serum calcium, phosphorus, alkaline phosphatase and vitamin D levels in the participants as it has already been suggested that thyroid hormones play an important role in the homeostasis of calcium and phosphorus levels by their direct action on bone turnover [17,18]. Previous studies carried out on serum calcium and phosphorus levels in thyroid disorders had conflicting results.…”

Section: Discussionmentioning

confidence: 99%

“…Mineral metabolism (calcium and phosphorus) is frequently disturbed in hyperthyroidism [16]. Thyroid hormones play an important role in the homeostasis of calcium and phosphorus levels by their direct action on bone turnover [17,18]. Previous studies carried out on serum calcium and phosphorus levels in thyroid disorders have had conflicting results.…”

Section: Introductionmentioning

confidence: 97%

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Incidence of Thyroid Diseases in Female Saudi Adults Visiting a Tertiary Care Hospital in Riyadh

Hasanato¹,

Mirah²,

Al-Shahrani³

et al. 2017

Epidemiology (Sunnyvale)

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Introduction: Diseases of the thyroid gland are common in adults and the prevalence is increasing in all parts of the world. Ethnicity and geographical locations also affect the prevalence of thyroid disorders along with the age, sex and iodine-intake by the different populations. The objective of our study is to examine the prevalence of thyroid dysfunction in female Saudi adults. It is a quantitative, observational, cross-sectional study involving 199 female Saudi adults visiting the King Khalid University Hospitals, Riyadh. Recruitment of subjects was done by random sampling.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Incidence of Thyroid Diseases in Female Saudi Adults Visiting a Tertiary Care Hospital in Riyadh

Hasanato¹,

Mirah²,

Al-Shahrani³

et al. 2017

Epidemiology (Sunnyvale)

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“…Consequently, thyroid cell damage, as well as direct enzyme blocking, may lead to insufficient hormone production, occasionally preceded by transient hyperthyroidism [2]. Both hypo-and hyperthyroidism are among the most common endocrine disorders [3,4,5]. In addition, elevated titers of anti-TPO were revealed in a wide range of diseases affecting various body organs, including Biermer's pernicious anaemia, viral hepatitis treated with INFα, systemic lupus erythematosus, insulin-dependent diabetes mellitus, breast cancer, vitiligo [6] and thyroid nodular disease [7,8].…”

Section: Introductionmentioning

confidence: 99%

Anti-thyroidal peroxidase antibodies are associated with thyrotropin levels in hypothyroid patients and in euthyroid individuals

Bromińska

Bromiński

Owecki

et al. 2017

Ann Agric Environ Med.

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Objective. The study was designed to evaluate the relationship between thyroid antibodies and gland dysfunction, with the aim of finding a clinically useful threshold value of thyreoperoxidase antibodies, which could prove to be predictive for thyroid failure. Materials and method. The study was conducted on 99 women, ages ranging from 18-91 years (mean age: 45.5 ±17.0), were treated as outpatients in the Department of Endocrinology, Metabolism and Internal Medicine. Analysis of serum samples for TSH concentration and anti-TPO titers was conducted. Results. The most common disorder was hypothyroidism. Anti-TPO titers above reference range values were observed in 35 patients (35.4%): 21 (60%) were hypothyroid and 11 (31.4 %) were euthyroid. The anti-TPO and TSH serum levels correlated both in patients with high thyroid antibody titers, and in the anti-TPO negative groups. To find the threshold value of anti-TPO that would help predict hypothyroidism, receiver operating curves were used. With this approach, TPO antibody titers over 17 IU/ml indicated hypothyroidism with a 90% sensitivity and 75% sensibility. Conclusion. It can be postulated that the cutoff values of anti-TPO in the general population should be decreased in order to improve autoimmune thyroid disorder screening. Obviously, using that margin may lead initially to the detection of some false positive subjects. However, with lower cut-off values, more patients can be enrolled into thyroid follow-up groups. In this way, many people could avoid complications of undiagnosed, insidious thyroid failure.

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“…Proposed mechanisms are: decreased synthesis in skin due to thyrotoxicosis-associated hyperpigmentation, decreased absorption due to steatorrhea and increased degradation due to hepatic enzyme stimulation. Serum calcium and phosphorous level may be low, normal or high depending on the severity of thyrotoxicosis and associated abnormalities [4,5]. Though bone mineral density is not available, low serum vitamin D with high alkaline phosphatase in presence of normal calcium/phosphorus level in the background of post-menopausal status is obvious in our patient.…”

Section: Discussionmentioning

confidence: 86%