2007
DOI: 10.1016/j.ijrobp.2006.08.051
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Thyroid disorders in patients treated with radiotherapy for head-and-neck cancer: A retrospective analysis of seventy-three patients

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Cited by 106 publications
(124 citation statements)
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“…[1][2][3][4][5][6][7][8][9][10][11][12] XRT causes microvascular and parenchymal damage to the gland, which results in decreased function several years after completing XRT. Eighty-five percent (52/61) of the patients included in this study demonstrated a measured decrease in the width of the thyroid gland on follow-up CT, with measurable changes occurring in several patients within the first quarter year following completion of XRT.…”
Section: Discussionmentioning
confidence: 99%
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“…[1][2][3][4][5][6][7][8][9][10][11][12] XRT causes microvascular and parenchymal damage to the gland, which results in decreased function several years after completing XRT. Eighty-five percent (52/61) of the patients included in this study demonstrated a measured decrease in the width of the thyroid gland on follow-up CT, with measurable changes occurring in several patients within the first quarter year following completion of XRT.…”
Section: Discussionmentioning
confidence: 99%
“…[1][2][3][4][5][6][7][8][9][10][11][12] The percentage of patients developing hypothyroidism during the study period is likely exaggerated because lack of clinical data on thyroid function was an exclusion criterion for the study. A disproportionate number of euthyroid patients were probably excluded because it may be easier to document positive signs and symptoms of a disorder rather than negative signs and symptoms.…”
Section: Discussionmentioning
confidence: 99%
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“…Although it is well known that RT induces thyroid functional changes and may induce different degrees of damage, it still represents a clinically underestimated problem. [4,7,8] The etiology of post-RT HT includes vascular damage, parenchymal cell damage, and autoimmune reactions. [9,10] Fajardo et al [11] have stated that damage to endothelial cells in thyroid capillary networks might be an important mechanism in both early and delayed radiation damage.…”
Section: Discussionmentioning
confidence: 99%
“…[3][4][5][6] However, thyroid dysfunction after RT for HNC still represents a clinically underestimated problem. [7] Our study is based on the question of "When should we be concerned for post-RT HT?" with assessment of multiple variables in patients treated with RT for HNCs.…”
mentioning
confidence: 99%