Thyroid dysfunction and breast cancer risk among women in the UK Biobank cohort

Tran, Thi-Van-Trinh; Maringe, Camille; Majano, Sara Benítez; Rachet, Bernard; Boutron‐Ruault, Marie‐Christine; Journy, Neige

doi:10.1002/cam4.3978

Cited by 12 publications

(4 citation statements)

References 41 publications

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“…UK cancer has an opportunity to deploy its unique integrated data intelligence platforms to address many of issues above. These systems of data capture and linkage enable formulation of datasets that include information on every cancer diagnosis, all hospital episodes and procedures, information on radiotherapy, surgery and SACT 114 as well as the opportunity to integrate genetic testing data, GP records and patient reported outcome measures [115][116][117][118][119] .…”

Section: Services and Systemsmentioning

confidence: 99%

The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan

Aggarwal,

Choudhury,

Fearnhead

et al. 2024

The Lancet Oncology

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Section: Services and Systemsmentioning

confidence: 99%

The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan

Aggarwal,

Choudhury,

Fearnhead

et al. 2024

The Lancet Oncology

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“…Initial investigations found that patients with hypothyroidism had higher risk of breast cancer [ 23 , 24 ]. However, other studies showed that hypothyroidism was associated with a reduced risk of this tumor [ 21 , 25 ] or that there was no significant relationship [ 13 , 17 , 26 – 31 ]. A meta-analysis including 12 studies showed that there was a 6% increase in risk for breast cancer among women with primary hypothyroidism [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Malignant neoplasms in people with hypothyroidism in Spain: A population-based analysis

Díez

Iglesias

2022

PLoS ONE

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Purpose The objective of this study was to determine the association between hypothyroidism and overall and site-specific cancer in Spanish population. Methods A cross-sectional study was performed using the population-based database BDCAP (Base de Datos Clínicos de Atención Primaria, primary care clinical database) to analyze the relative risk of cancer in Spanish population with hypothyroidism. Results In a total of 2,414,165 patients diagnosed with hypothyroidism in BDCAP in 2019, the relative risk (OR) of cancer, compared to the non-hypothyroid population, was 1.73 (1.72–1.74) (P<0.0001). The higher risk was observed in both men (OR 2.15 [2.13–2.17]; P<0.0001) and women (OR 1.67 [1.636–1.68]; P<0.0001). However, hypothyroid persons aged 65 years or older had a reduced risk of cancer (OR 0.98 [0.97–0.98]; P<0.0001). In addition, hypothyroid patients aged 65 or over showed a decreased risk of cancers of the bladder, colorectal, gastric, pancreatic and prostate. Socioeconomic characteristics such as income level, municipality size, country of birth and employment situation had limited influence on the association between hypothyroidism and cancer. However, hypothyroid patients receiving replacement therapy exhibited higher cancer risk compared with patients without treatment (OR 1.30 [1.28–1.31]; P<0.0001). Conclusion Spanish hypothyroid patients of both genders have a risk of overall cancer higher than that found in non-hypothyroid population. However, people over 65 years have a reduced risk of various malignancies. This peculiarity of hypothyroidism should be considered by the health authorities.

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“…Кроме того, обнаружено, что тироксин -фактор пролиферации клеток РМЖ in vitro и что тироксин может стимулировать альфа-зависимую от ядерного рецептора эстрогена пролиферацию клеток РМЖ, несущих этот рецептор [38]. Однако по данным одного из исследований риск РМЖ варьировал в зависимости от статуса лечения гипертиреоза, при этом риск РМЖ у женщин, получавших лечение от гипертиреоза, был на 38% выше по сравнению с таковым у женщин без дисфункции щитовидной железы [39]. Среди женщин в постменопаузе связь между Т 4 и риском развития РМЖ также была сильнее у женщин с ожирением, у которых концентрация эстрогена в крови была выше, чем у женщин с нормальным весом [40].…”

Section: рак щитовидной железыunclassified

Phenomenon of hormone-dependent polyneoplasia of the female reproductive system

Klyukina

Sosnova

Ishchenko

et al. 2023

V.F.Snegirev Archives of Obstetrics and Gynecology

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BACKGROUND: Primary multiplicity of malignant tumors of the female reproductive system is the least studied area of clinical oncology. In addition, the steady rise in the number of patients and various localizations of polyneoplasia with lesions of the female reproductive organs necessitate a detailed study of this problem. AIM: This study aimed to determine the incidence and risk factors and describe the clinical aspects of polyneoplasia of the female reproductive system for 20102021 in women seen at the Medical and Rehabilitation Center of the Ministry of Health of Russia, Moscow, and the University Clinical Hospital No. 4 of the I.M. Sechenov First Moscow State Medical University. MATERIALS AND METHODS: We conducted a retrospective analysis of the case records of 147 patients with a confirmed diagnosis of polyneoplasia of the female reproductive system for 20102021, which accounted for 3.6% of all newly diagnosed neoplasms of the female reproductive system in the above medical institutions. Moreover, a continuous sampling method was used. RESULTS: Breast cancer was the most frequent first tumor, combined with cancer of the contralateral breast in 27 (42.1%) patients, cancer of the uterine body in 4 (6.25%) patients, ovarian cancer in 4 (6.25%) patients, colon cancer in 4 (6.25%) patients, and thyroid cancer in 1 (1.5%) patient. Cancer of the uterine body was combined with breast cancer in 10 (35.7%) patients, ovarian cancer in 2 (7.1%) patients, thyroid cancer in 2 (7.1%) patients, and colon cancer in 3 (11.1%) patients. Endometrioid adenocarcinoma, pathogenic variant I was determined in 20 (71.4%) cases according to the histological structure. Thyroid cancer was detected in 7 (5.6%) cases; in all cases, it developed metachronously, and it was combined as the initial tumor with breast cancer in 1 (14.3%) case, uterine body cancer in 2 (28.5%) cases, and ovarian cancer in 1 (14.3%) case. As the second tumor, it was also combined with uterine body cancer in 2 (28.5%) cases and ovarian cancer in 1 (14.3%) case. The risk factors assessment led to the identification of several factors that are common in patients with hormone-dependent forms of primary multiple cancer, including obesity, diabetes mellitus, irregular menstrual cycle, history of proliferative diseases of the mammary glands, intake of thyroid drugs, uterine hyperplastic processes, and hypothyroidism. CONCLUSIONS: Understanding the different aspects of the development and course of hormone-dependent polyneoplasia of the female reproductive system will help in developing approaches for follow-up monitoring of women who have been treated for a primary tumor and are at risk of developing a subsequent tumor of hormone-dependent organs, to prevent the recurrence of the disease and predict the subsequent tumor and ensure its timely detection.

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Thyroid dysfunction and breast cancer risk among women in the UK Biobank cohort

Cited by 12 publications

References 41 publications

The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan

The future of cancer care in the UK—time for a radical and sustainable National Cancer Plan

Malignant neoplasms in people with hypothyroidism in Spain: A population-based analysis

Phenomenon of hormone-dependent polyneoplasia of the female reproductive system

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