Thyroid dysfunction and liver injury following alpha-interferon treatment of chronic viral hepatitis

Berris, B.; Sv, Feinman

doi:10.1007/bf01296413

Cited by 64 publications

(21 citation statements)

References 12 publications

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“…The same was found by Bareca et al, who reported no change in serum free testosterone and LH concentrations, measured every two months during IFN-a (3´10 6 U) thrice weekly for six months (15). Since we found a decrease in testosterone concentrations within twelve hours after one injection of rhIFN-a, which was also found by Orava et al during short term treatment with rhIFN-a (<10 days) (12), whereas no change was found during chronic administration (6±12 months) of rhIFN-a (14,15), it is possible that there is a difference between the acute and chronic effects of rhIFN-a, such as has been documented for the effects of rhIFN-a on thyroid hormone concentrations (6,7,10). Since in our study no measurements of testosterone concentrations were performed later than 12 h after rhIFN-a administration, no conclusions can be drawn about the duration of the hormone effect.…”

Section: Discussionsupporting

confidence: 49%

Acute effects of interferon-alpha administration on testosterone concentrations in healthy men

Corssmit

Endert

Sauerwein

et al. 2000

European Journal of Endocrinology

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Objective: Recombinant human interferon alpha (rhIFN-a) is used therapeutically in malignant disorders and chronic hepatitis. The present study was assessed to study the effects of rhIFN-a on the hypothalamic±pituitary±testicular (HPT) axis. Design and methods: We performed a saline-controlled cross-over study in six healthy men, sequentially measuring the serum concentrations of gonadotropins, testosterone, the free androgen index (FAI) and sex hormone-binding globulin (SHBG) after a bolus subcutaneous injection of rhIFN-a. Results: rhIFN-a induced a sustained decrease of both testosterone (from 19.5 6 1.88 to a nadir of 5.49 6 0.51 nmol/l at the end of the study) and FAI (from 98.7 6 14.7 to a nadir of 32.1 6 5.3 at the end of the study), whereas concentrations of LH, FSH and SHBG were not different between the two studies. Conclusions: Our results suggest that rhIFN-a affects the HPT axis at the testicular level, either directly or indirectly, and changes feedback relationships between the pituitary and the testis.

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Section: Discussionsupporting

confidence: 49%

Acute effects of interferon-alpha administration on testosterone concentrations in healthy men

Corssmit

Endert

Sauerwein

et al. 2000

European Journal of Endocrinology

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“…IFN therapy was effective in patient 1, but ineffective in patients 2, 3, and 4. (Hanafusa et al 1983;Berris and Feinman, 1991 …”

Section: Case Reportmentioning

confidence: 99%

Thyroid Dysfunction Induced by Interferon Therapy for the Treatment of Hepatitis Type C. A Report of 4 Cases.

et al. 1995

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Summary: We describe 4 patients with onset or aggravation of thyroid dysfunction induced by interferon (IFN) treatment of hepatitis type C. All 4 patients were females; 2 had hyperthyroidism and 2 had hypothyroidism during or after IFN therapy. The onset or aggravation of thyroid dysfunction occurred during administration of IFN in 1 patient and 4 weeks after the end of IFN therapy in the remaining 3 patients. The 2 patients who demonstrated hyperthyroidism were euthyroid and negative for thyroid autoantibodies before receiving IFN therapy. The remaining 2 patients who demonstrated hypothyroidism were positive for thyroid autoantibodies before IFN therapy. One of these patients had a slight decrease in thyroid function before IFN therapy. Anti-thyroid stimulating hormone (TSH) receptor antibodies became positive in all 4 patients. Since there may have been a causal relationship between IFN therapy and the onset or aggravation of thyroid dysfunction, IFN therapy should be administered with caution.

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“…28 İnterferon (IFN)-alfa kullanımı sırasında tiroid disfonksiyonu gelişebildiği bundan yaklaşık 20 yıl önce gösterilmiştir. 29,30 Daha sonra yapılan çalış-malarda, IFN-beta1b kullanımı ile ilişkili tiroid disfonksiyonu %8,3-33 arasında gösterilmiştir. [31][32][33][34] Durelli ve ark., IFN-beta1b tedavisi sonrasında bazı hastalarda tiroid otoantikorlarının geliştiğini saptamışlardır.…”

Section: Discussionunclassified

The Prevalence of Thyroid Autoantibodies in Multiple Sclerosis Patients

Gençer¹,

Türkoğlu²,

Çetinkaya³

et al. 2015

Turkiye Klinikleri J Neur

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Thyroid dysfunction and liver injury following alpha-interferon treatment of chronic viral hepatitis

Cited by 64 publications

References 12 publications

Acute effects of interferon-alpha administration on testosterone concentrations in healthy men

Acute effects of interferon-alpha administration on testosterone concentrations in healthy men

Thyroid Dysfunction Induced by Interferon Therapy for the Treatment of Hepatitis Type C. A Report of 4 Cases.

The Prevalence of Thyroid Autoantibodies in Multiple Sclerosis Patients

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