Thyroid dysfunction and subfertility

Cho, Moon Kyoung

doi:10.5653/cerm.2015.42.4.131

Cited by 40 publications

(28 citation statements)

References 28 publications

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“…As case 1 had a smaller r (X) chromosome compared to case 2, we analysed the additional genes deleted and found that the extra region deleted in case 1 (Xq21.33-Xq22.1) were harbouring genes involved in thyroid hormone signalling, insulin receptor signalling, meiosis regulation, cell cycle regulation and chromatin organization. Alterations in these pathways are reported to be responsible for ovarian dysfunction [1,5,9,31,36,46].…”

Section: Discussionmentioning

confidence: 99%

Molecular cytogenetic characterization of two Turner syndrome patients with mosaic ring X chromosome

Chauhan

Jaiswal

Lakhotia

et al. 2016

J Assist Reprod Genet

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Purpose In the present study, we reported two cases of TS with mosaic ring X chromosome showing common clinical characteristics of TS like growth retardation and ovarian dysfunction. The purpose of the present study was to cytogenetically characterize both cases. Methods Whole blood culture and G-banding were performed for karyotyping the cases following standard protocol. Origin of the ring chromosome and degree of mosaicism were further determined by fluorescence in situ hybridization (FISH). Breakpoints and loss of genetic material in formation of different ring X chromosomes r (X) in cases were determined with the help of cytogenetic microarray. Results Cases 1 and 2 with ring chromosome were cytogenetically characterized as 45, X [114]/46Xr (X) (p22.11q21.32) [116] and 45, X [170]/46, Xr (X) (p22.2q21.33) [92], respectively. Sizes of these ring X chromosomes were found to be~7 5 and~95 Mb in cases 1 and 2, respectively, using visual estimation as part of cytogenetic observation. In both cases, we observed breakpoints on Xq chromosome were within relatively narrow region between Xq21.33 and Xq22.1 compared to regions in previously reported cases associated with ovarian dysgenesis. Conclusions Our observation agrees with the fact that despite of large heterogeneity, severity of the cases with intact Xinactive specific transcript (XIST) is dependent on degree of mosaicism and extent of Xq deletion having crucial genes involved directly or indirectly in various physiological involving ovarian cyclicity.

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Section: Discussionmentioning

confidence: 99%

Molecular cytogenetic characterization of two Turner syndrome patients with mosaic ring X chromosome

Chauhan

Jaiswal

Lakhotia

et al. 2016

J Assist Reprod Genet

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“…The prevalence of SCH in sub fertile women has been reported to vary from 0.7% to 43%. 9 History of infertility was there in 20.4% of present study population. Among them Subclinical hypo and hyperthyroidism was observed to an extent of 28% in each group.…”

Section: Resultsmentioning

confidence: 72%

Routine screening of antenatal population for thyroid disorders-mandatory

Hymavathi

Gottipati

Jakka

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Thyroid dysfunction is commonly seen in pregnant women causing adverse maternal and fetal effects. Routine screening of antenatal population for the same will be helpful for successful pregnancy outcomes. The objective of this study is to detect and treat antenatal women with Thyroid dysfunction to avoid deleterious maternal/ fetal effects.Methods: The present study is a hospital based prospective study conducted in the department of Obstetrics and Gynaecology of Narayana Medical College and Hospital(NMCH), Nellore, Andhra Pradesh, India. 1000 pregnant women were randomly recruited into this study. Apart from routine antenatal investigations, Thyroid function tests (TFT) - Thyroid stimulating hormone (TSH), freeT4 (fT4) and Thyroid peroxidase antibody (TPO Ab) are done for all the recruited women at the first visit of antenatal booking and individual Thyroid tests are repeated as required.Results: Following the TFT the study population is classified into pregnancies with euthyroidism‚ subclinical/ overt hypothyroidism and hyperthyroidism. The prevalence of Thyroid disorders in present study was 12.7% of which hypothyroidism noted in 10.3% (subclinical 6.9% and overt 3.4%) while hyperthyroidism seen in 2.4% (subclinical 1.8% and overt 0.6%). The various pregnancy complications, labour and neonatal outcomes have been analyzed.Conclusions: Thyroid dysfunction in pregnancy affects the health of the mother as well as the baby. Screening for Thyroid dysfunction should be performed as part of the routine antenatal work-up for successful pregnancy outcomes.

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“…For our patient, the time from adopting a gluten-free diet to delivery of a baby was 17 months. Infertility is also associated with thyroid autoimmunity (14), and increased prevalence of hypothyroidism among women with celiac disease have been reported (15). Co-existent autoimmune thyroid disease and celiac disease may be due to a common genetic predisposition.…”

Section: Discussionmentioning

confidence: 99%

Successful Pregnancy on a Gluten-Free Diet in a Woman with Seven Miscarriages and Nonceliac Gluten Sensitivity

Bennett

Gupta

2018

AACE Clinical Case Reports

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Objective: To describe a case in which a glutenfree diet led to a successful full-term delivery in a woman with recurrent miscarriages and nonceliac gluten sensitivity (NCGS).Methods: Reduced incidences of spontaneous abortions have been reported in patients with celiac disease who adhere to a gluten-free diet, but little is known about improvement in reproductive issues in women with NCGS. We present a case of a woman with multiple miscarriages who improved on a gluten-free diet.Results: A 33-year-old woman presented with history of hypothyroidism and recurrent first-trimester fetal loss. On exam, body mass index was 24.9 kg/m 2 , and she did not appear cushingoid. She was on levothyroxine, and thyroid function tests were within normal limits. Thyroid peroxidase antibody and anti-phospholipid antibody were negative. Although she denied gastrointestinal symptoms, undiagnosed celiac disease was considered, as she had family members with celiac disease. Anti-gliadin immunoglobulin (Ig)G antibody was elevated, while tissue transglutaminase IgA and anti-endomysial IgA were negative. Esophagogastroduodenoscopy and biopsy showed normal mucosa. These findings were consistent with a diagnosis of NCGS. A trial with a gluten-free diet was initiated. She became pregnant again and was able to carry the baby to full-term with delivery.Conclusion: While the exact effect of NCGS is yet to be determined, immunologic changes in placental function may account for recurrent fetal loss since gliadin is abundant in the extravillous trophoblast that attaches the placenta to the mother. (AACE Clinical Case Rep. 2018;4:e443-e446) Abbreviations: ACTH = adrenocorticotropic hormone; Ig = immunoglobulin; NCGS = nonceliac gluten sensitivity

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Thyroid dysfunction and subfertility

Cited by 40 publications

References 28 publications

Molecular cytogenetic characterization of two Turner syndrome patients with mosaic ring X chromosome

Molecular cytogenetic characterization of two Turner syndrome patients with mosaic ring X chromosome

Routine screening of antenatal population for thyroid disorders-mandatory

Successful Pregnancy on a Gluten-Free Diet in a Woman with Seven Miscarriages and Nonceliac Gluten Sensitivity

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